Vaccination for Middle Ear Infection
Launched by NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS (NIDCD) · Dec 9, 2002
Trial Information
Current as of May 19, 2025
Completed
Keywords
ClinConnect Summary
Acute otitis media (OM) and OM with effusion are common childhood diseases. Nontypeable Haemophilus influenzae (NTHi) is a leading cause of OM and respiratory infections in older individuals. Currently, there is no vaccine for NTHi infection. Studies indicate that serum bactericidal antibodies are associated with protection from NTHi infection. We predict that serum antibodies with bactericidal activity to the lipooligosaccharide (LOS), a major surface antigen and virulence factor of NTHi, will confer immunity to this pathogen. LOS of NTHi is too toxic to administer to humans and detoxified...
Gender
ALL
Eligibility criteria
- • Healthy volunteers between ages 18 and 35 years.
- • Not pregnant or planning to become pregnant in next six months.
- • HIV negative.
- • Hepatitis B Negative.
- • No chronic Respiratory Tract Infections.
- • No history of abnormal immune system.
- • No severe or multiple allergies.
About National Institute On Deafness And Other Communication Disorders (Nidcd)
The National Institute on Deafness and Other Communication Disorders (NIDCD) is a prominent agency within the National Institutes of Health (NIH) dedicated to advancing research and understanding of hearing, balance, taste, smell, voice, speech, and language disorders. Through rigorous clinical trials and innovative research initiatives, the NIDCD aims to improve the diagnosis, treatment, and prevention of communication disorders, ultimately enhancing the quality of life for individuals affected by these conditions. The institute fosters collaboration among researchers, healthcare professionals, and patients to translate scientific discoveries into effective clinical practices and public health strategies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bethesda, Maryland, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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