The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Dec 9, 2002

Keywords

ClinConnect Summary

The renin angiotensin system (RAS) plays an important physiological and pathophysiological role in the control of blood pressure and plasma volume. Inhibition of the RAS is useful in the treatment of hypertension, cardiac failure and in some patients with myocardial infarction. Several recent clinical trials with angiotensin converting enzyme inhibitors (ACEI) have shown that they also reduce the incidence of myocardial infarction, but the mechanisms underlying this anti-ischemic effect are poorly understood. ACEI reduce angiotensin II synthesis and prevent bradykinin degradation. Results f...

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Eligibility criteria

• • Patients over 18 years with endothelial dysfunction requiring diagnostic cardiac catheterization.
• • Normal volunteers or patients undergoing catheterization who have normal coronary arteries without risk factors for atherosclerosis will be used as controls.
• • No unstable angina.
• • No significant left main disease (greater than 50% stenosis).
• • No recent myocardial infarction (less than 1 month).
• • No pregnancy, lactation.
• • No allergy to losartan.
• • No renal failure (creatinine greater than 2.5 mg/dl).
• • Ability to withdraw ACE inhibitors.