Structure of the Herpes Simplex Virus Receptor

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Nov 3, 1999

Keywords

ClinConnect Summary

Herpes simplex virus (HSV) causes genital, orolabial, or cutaneous lesions, keratitis, and encephalitis. Recently cellular receptors for HSV were isolated. The purpose of this study is to identify polymorphisms in the sequence of HSV receptor, cytokines or chemokines and to determine whether these polymorphisms correlate with susceptibility to infection by HSV or with symptoms of HSV. Blood samples from individuals who are seronegative, or seropositive (with or without symptoms of infection) for HSV-2 will be analyzed to determine the sequences of the HSV receptors, cytokines, chemokines, o...

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• HSV-2 Seronegative Patients:
• • Individuals known or likely to be seronegative for HSV-2 will be recruited.
• • All racial, gender, and ethnic groups will be considered.
• • Adult volunteers at least 18 years of age.
• • Volunteers who were seronegative for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot.
• • Volunteers are willing to allow investigators to store their blood.
• HSV-2 seropositive patients (with or without symptoms):
• • All racial and ethnic groups will be considered.
• • Volunteers who were seropositive for HSV-2 (regardless of HSV-1 serology) confirmed by Western blot.
• • Volunteers are willing to allow investigators to store their blood.
• Normal Controls:
• • To determine the frequency of a genetic polymorphism in a population that has not had prior screening for HSV, blood may be obtained from normal control blood donors.