Evaluation of Patients With HAM/TSP

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Nov 3, 1999

Keywords

ClinConnect Summary

This clinical trial is studying a rare condition called Human T-lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which affects some people who have the HTLV-I virus. The goal is to understand how this condition develops over time and to explore changes in the immune system and the virus itself. Researchers will track the health of participants through regular check-ups and tests, including neurological exams and blood samples, to learn more about the disease and how it affects individuals differently.

To participate in this study, you need to be diagnosed with HAM/TSP based on specific guidelines or have a family member who is HTLV positive. Healthy volunteers who are willing to help are also welcome. Participants will undergo various evaluations and tests throughout the study. It’s important to note that anyone under 18 years old will not be eligible for this trial. By joining, participants may contribute valuable information that could help improve understanding and treatment of this condition in the future.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• Participants that meet one of the following criteria:
• • Test positive for HTLV infection (positive HTLV-1 ELISA followed by a positive Western blot)
• • Positive HTLV ELISA but a Western Blot that only partially fulfills the above criteria (seroindeterminate)
• • Have a family member/significant other who is HTLV positive, and may have been exposed to the virus
• • Healthy volunteer AND
• • Willingness to participate in the protocol evaluations and procedures.
• EXCLUSION CRITERIA:
• • Unwillingness or inability to participate in the protocol evaluations and procedures.
• • The presence of any medical, social, or psychiatric conditions that in the opinion of the investigator may affect the safety of the patients or compliance with the protocol.
• • Patients/healthy volunteers under the age of 18 are excluded.

Trial Officials