Nctid:
NCT00001780
Payload:
{"hasResults"=>false, "derivedSection"=>{"miscInfoModule"=>{"versionHolder"=>"2024-09-05"}, "conditionBrowseModule"=>{"meshes"=>[{"id"=>"D000009069", "term"=>"Movement Disorders"}, {"id"=>"D000016472", "term"=>"Motor Neuron Disease"}, {"id"=>"D000000690", "term"=>"Amyotrophic Lateral Sclerosis"}, {"id"=>"D000003711", "term"=>"Demyelinating Diseases"}, {"id"=>"D000016464", "term"=>"Lysosomal Storage Diseases"}], "ancestors"=>[{"id"=>"D000002493", "term"=>"Central Nervous System Diseases"}, {"id"=>"D000009422", "term"=>"Nervous System Diseases"}, {"id"=>"D000019636", "term"=>"Neurodegenerative Diseases"}, {"id"=>"D000009468", "term"=>"Neuromuscular Diseases"}, {"id"=>"D000013118", "term"=>"Spinal Cord Diseases"}, {"id"=>"D000057177", "term"=>"TDP-43 Proteinopathies"}, {"id"=>"D000057165", "term"=>"Proteostasis Deficiencies"}, {"id"=>"D000008659", "term"=>"Metabolic Diseases"}, {"id"=>"D000008661", "term"=>"Metabolism, Inborn Errors"}, {"id"=>"D000030342", "term"=>"Genetic Diseases, Inborn"}], "browseLeaves"=>[{"id"=>"M12029", "name"=>"Movement Disorders", "asFound"=>"Movement Disorders", "relevance"=>"HIGH"}, {"id"=>"M18879", "name"=>"Motor Neuron Disease", "asFound"=>"Motor Neuron Disease", "relevance"=>"HIGH"}, {"id"=>"M4024", "name"=>"Amyotrophic Lateral Sclerosis", "asFound"=>"Motor Neuron Disease", "relevance"=>"HIGH"}, {"id"=>"M6909", "name"=>"Demyelinating Diseases", "asFound"=>"Demyelinating Diseases", "relevance"=>"HIGH"}, {"id"=>"M5134", "name"=>"Bone Marrow Diseases", "relevance"=>"LOW"}, {"id"=>"M18871", "name"=>"Lysosomal Storage Diseases", "asFound"=>"Lysosomal Storage Diseases", "relevance"=>"HIGH"}, {"id"=>"M15415", "name"=>"Sclerosis", "relevance"=>"LOW"}, {"id"=>"M5742", "name"=>"Central Nervous System Diseases", "relevance"=>"LOW"}, {"id"=>"M21558", "name"=>"Neurodegenerative Diseases", "relevance"=>"LOW"}, {"id"=>"M12411", "name"=>"Neuromuscular Diseases", "relevance"=>"LOW"}, {"id"=>"M15915", "name"=>"Spinal Cord Diseases", "relevance"=>"LOW"}, {"id"=>"M28759", "name"=>"TDP-43 Proteinopathies", "relevance"=>"LOW"}, {"id"=>"M28747", "name"=>"Proteostasis Deficiencies", "relevance"=>"LOW"}, {"id"=>"M11639", "name"=>"Metabolic Diseases", "relevance"=>"LOW"}, {"id"=>"M11641", "name"=>"Metabolism, Inborn Errors", "relevance"=>"LOW"}, {"id"=>"M23686", "name"=>"Genetic Diseases, Inborn", "relevance"=>"LOW"}, {"id"=>"T349", "name"=>"Amyotrophic Lateral Sclerosis", "asFound"=>"Motor Neuron Disease", "relevance"=>"HIGH"}, {"id"=>"T3395", "name"=>"Leukodystrophy", "relevance"=>"LOW"}, {"id"=>"T4699", "name"=>"Primary Lateral Sclerosis", "relevance"=>"LOW"}], "browseBranches"=>[{"name"=>"Nervous System Diseases", "abbrev"=>"BC10"}, {"name"=>"All Conditions", "abbrev"=>"All"}, {"name"=>"Nutritional and Metabolic Diseases", "abbrev"=>"BC18"}, {"name"=>"Blood and Lymph Conditions", "abbrev"=>"BC15"}, {"name"=>"Diseases and Abnormalities at or Before Birth", "abbrev"=>"BC16"}, {"name"=>"Symptoms and General Pathology", "abbrev"=>"BC23"}, {"name"=>"Rare Diseases", "abbrev"=>"Rare"}]}}, "protocolSection"=>{"designModule"=>{"studyType"=>"OBSERVATIONAL", "enrollmentInfo"=>{"count"=>450}}, "statusModule"=>{"overallStatus"=>"COMPLETED", "startDateStruct"=>{"date"=>"1998-02"}, "expandedAccessInfo"=>{"hasExpandedAccess"=>false}, "statusVerifiedDate"=>"2005-11", "completionDateStruct"=>{"date"=>"2005-11"}, "lastUpdateSubmitDate"=>"2008-03-03", "studyFirstSubmitDate"=>"1999-11-03", "studyFirstSubmitQcDate"=>"1999-11-03", "lastUpdatePostDateStruct"=>{"date"=>"2008-03-04", "type"=>"ESTIMATED"}, "studyFirstPostDateStruct"=>{"date"=>"1999-11-04", "type"=>"ESTIMATED"}}, "conditionsModule"=>{"keywords"=>["Myelopathy", "Demyelination", "Leukodystrophy", "Motor Neuron Disease", "Movement Disorders", "Normal Volunteer"], "conditions"=>["Demyelinating Disease", "Healthy", "Lysosomal Storage Disease", "Motor Neuron Disease", "Movement Disorder"]}, "referencesModule"=>{"references"=>[{"pmid"=>"2233862", "type"=>"BACKGROUND", "citation"=>"Eisen AA, Shtybel W. AAEM minimonograph #35: Clinical experience with transcranial magnetic stimulation. Muscle Nerve. 1990 Nov;13(11):995-1011. doi: 10.1002/mus.880131102."}, {"pmid"=>"8740220", "type"=>"BACKGROUND", "citation"=>"Wassermann EM, Samii A, Mercuri B, Ikoma K, Oddo D, Grill SE, Hallett M. Responses to paired transcranial magnetic stimuli in resting, active, and recently activated muscles. Exp Brain Res. 1996 Apr;109(1):158-63. doi: 10.1007/BF00228638."}, {"pmid"=>"1705221", "type"=>"BACKGROUND", "citation"=>"Muller K, Homberg V, Lenard HG. Magnetic stimulation of motor cortex and nerve roots in children. Maturation of cortico-motoneuronal projections. Electroencephalogr Clin Neurophysiol. 1991 Feb;81(1):63-70. doi: 10.1016/0168-5597(91)90105-7."}]}, "descriptionModule"=>{"briefSummary"=>"Transcranial Magnetic Stimulation (TMS) is a non-invasive technique to gather information about brain function. It is very useful when studying the areas of the brain related to motor activity (motor cortex, corticospinal tract, spinal cord and nerve roots). The procedure is conducted by transmitting a magnetic signal into the brain to stimulate an area of the body. Electrodes (small pieces of metal taped to areas of the body) are used in order to measure electrical activity. A magnetic signal is sent from a metal instrument held close to the patient's head, to an area of the brain responsible for motor activity of a certain area of the body. The electrodes pick up and record the electrical activity in the muscles.\n\nThis study will employ the use of TMS to diagnose neurological disorders that affect the motor cortex or the corticospinal tract. Normal subjects are sometimes studied to investigate normal activity of the nervous system and to train doctors in clinical neurophysiology and electrodiagnostic medicine at the National Institutes of Health (NIH).", "detailedDescription"=>"This protocol outlines the use of magnetic stimulation as a diagnostic tool in patients with suspected dysfunction of central motor pathways or nerve roots and as a tool to localize and characterize suspected corticospinal abnormalities in neurologic disorders and systemic disorders with neurological manifestations. The protocol is intended for clinical use.\n\nTranscranial magnetic stimulation has been used for diagnosis of neurologic disorders since 1987. The principles of magnetic stimulation and its use for diagnosis are described in current textbooks of clinical neurophysiology as a routine procedure and should be included in the training program for fellows in clinical neurophysiology and electrodiagnostic medicine at NIH.\n\nThe magnetic stimuli are to be given as single or paired pulses at repetition rates less than 1 per second."}, "eligibilityModule"=>{"sex"=>"ALL", "stdAges"=>["CHILD", "ADULT", "OLDER_ADULT"], "healthyVolunteers"=>true, "eligibilityCriteria"=>"INCLUSION CRITERIA:\n\nAdult patients with weakness or motor dysfunction.\n\nChildren and adolescents with corticospinal tract signs.\n\nNormal volunteers, adults.\n\nNormal volunteers, children aged 4-17.\n\nEXCLUSION CRITERIA:\n\nPregnant women.\n\nSubjects with implanted devices: pacemakers, medication pumps or defibrillators.\n\nSubjects with metal in the cranium except the mouth.\n\nSubjects with intracardiac lines.\n\nNormal subjects with history of seizures."}, "identificationModule"=>{"nctId"=>"NCT00001780", "briefTitle"=>"Magnetic Stimulation of the Human Nervous System", "organization"=>{"class"=>"NIH", "fullName"=>"National Institutes of Health Clinical Center (CC)"}, "officialTitle"=>"Stimulation of the Human Central and Peripheral Nervous System With a Magnetic Stimulator", "orgStudyIdInfo"=>{"id"=>"980065"}, "secondaryIdInfos"=>[{"id"=>"98-N-0065"}]}, "contactsLocationsModule"=>{"locations"=>[{"zip"=>"20892", "city"=>"Bethesda", "state"=>"Maryland", "country"=>"United States", "facility"=>"National Institute of Neurological Disorders and Stroke (NINDS)", "geoPoint"=>{"lat"=>38.98067, "lon"=>-77.10026}}]}, "sponsorCollaboratorsModule"=>{"leadSponsor"=>{"name"=>"National Institute of Neurological Disorders and Stroke (NINDS)", "class"=>"NIH"}}}}
