G-CSF for Granulocyte Donation
Launched by NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER (CC) · Nov 3, 1999
Current as of November 28, 2023
The administration of granulocyte colony-stimulating factor (G-CSF) to increase the white blood cell count in granulocyte donors prior to donation is becoming an increasingly common practice. G-CSF is given subcutaneously to the donor on the day prior to donation, generally 12 to 24 hours before the start of apheresis. It would be advantageous to be able to give G-CSF and collect granulocytes on the same day. However, the single most important factor in optimizing granulocyte collection is the donor's pre-collection granulocyte count. Therefore, any decrease in count would result in a less ...
- Male and female subjects.
- Must be 18 years of age or older.
- Subjects must pass the health criteria for blood donors established by the American Association of Blood Banks.
- No subjects who are pregnant or lactating females.
- No subjects with uncontrolled hypertension, heart disease, diabetes, history of allergic reactions to G-CSF, history of allergic reactions to E. coli, abnormal hemoglobin or white blood cell counts, a malignancy, asthma, taking prednisone or using an inhalant.
- No hemoglobin less than 11.0 or greater than 19.0 gm/dL
- No platelet counts less than 140 x 10(9)/L or greater than 500 x 10(9)/L.
- No absolute neutrophil count less than 1.5 x 10(9/)/L or greater than 10.0 x 10(9)/L.
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland, United States
All reviews come from applied patients