Effect of Pregnancy on Uveitis

Launched by NATIONAL EYE INSTITUTE (NEI) · Dec 9, 2002

Keywords

ClinConnect Summary

Pregnancy is thought to be associated with the remediation of some disease and exacerbation of other conditions. Anecdotal case reports suggest that uveitis may remit or improve during pregnancy and recur in the postpartum period. This observation is supported by findings in an experimental autoimmune uveitis model in mice. We propose to study the natural history of ocular inflammation in a series of pregnant women who have had ocular inflammation (uveitis) in the two year period prior to becoming pregnant. Women will be enrolled between 2 and 20 completed weeks of gestation at which time t...

Gender

FEMALE

Eligibility criteria

• • Females with a history of unilateral or bilateral immune-mediated, non-infectious inflammatory ocular disease that required topical and/or systemic immunosuppresive medications at least once in the past two years or who are currently under treatment for unilateral or bilateral non-infectious ocular inflammation and having diagnosed uveitis, scleritis, or autoimmune corneal disorders in the past two years.
• • First and second trimester pregnancy.
• • Informed consent from the patient.
• • No pregnancy complications which require medical treatment and special obstetric care.
• • No hematolgical disorder that would preclude blood draws for investigational purposes.
• • No current ocular or systemic infection.
• • No current malignancy.
• • No current endocrine disorders.