Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-Disease

Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Nov 3, 1999

Keywords

ClinConnect Summary

This protocol has been written to make available apheresis collections from volunteers matched to various degrees with recipients in order to test and, if necessary refine, the selective immunodepletion procedure prior to introducing it in a clinical trial.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Family members of patients admitted to NHLBI allogeneic BMT protocols.
• • Ages 18 and older and less than age 65.
• • Parent of patient (obligate haplotype match) OR HLA 3/6, 4/6, 5/6, or 6/6 match with patient.
• • Research apheresis available from patient.
• EXCLUSION CRITERIA:
• • Pregnancy or lactation.
• • HLA type unknown.
• • More than one haplotype mismatch with patient.
• • History of any immunosuppressive disease.
• • History of chronic viral antigenic stimulus.
• • Venous access inadequate.

Trial Officials