Lung Disease Associated With Rheumatoid Arthritis

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Nov 3, 1999

Keywords

ClinConnect Summary

Pulmonary fibrosis is an extra-articular manifestation of rheumatoid arthritis whose etiology remains uncertain. Although the clinical course of many individuals with this disorder can mimic that observed in patients with idiopathic pulmonary fibrosis, the natural history of fibrotic lung disease associated with rheumatoid arthritis remains largely undefined. It is the intent of this clinical protocol to (1) estimate the prevalence of pulmonary fibrosis in individuals with rheumatoid arthritis, (2) define the natural history of pulmonary fibrosis in patients with rheumatoid arthritis, (3) e...

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Eligibility criteria

• * INCLUSION CRITERIA:
• Non-smokers (never smoked or no smoking within the previous 2 years) who are 21 years of age or older with any of the following:
• • Rheumatoid arthritis with biopsy-proven pulmonary fibrosis or;
• • Rheumatoid arthritis only, or;
• • Biopsy-proven idiopathic pulmonary fibrosis.
• EXCLUSION CRITERIA:
• • Forced expiratory volume in one second (FEV1) less than 1L.
• • Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium).
• • Chronic cardiopulmonary disorders other than pulmonary fibrosis.
• • Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
• • Non-rheumatoid arthritis.
• • Viral infections associated with pulmonary fibrosis (e.g., hepatitis B, hepatitis C, human immunodeficiency virus).
• • Uncorrectable bleeding diathesis.
• • Pregnancy or lactation.