Search / Trial NCT00001876

Lung Disease Associated With Rheumatoid Arthritis

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Nov 3, 1999

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Trial Information

Current as of December 10, 2023

Completed

Keywords

Interstitial Lung Disease Collagen Vascular Disease Extracellular Matrix Pulmonary Function Dtpa Lung Clearance Scan Natural History

Description

Pulmonary fibrosis is an extra-articular manifestation of rheumatoid arthritis whose etiology remains uncertain. Although the clinical course of many individuals with this disorder can mimic that observed in patients with idiopathic pulmonary fibrosis, the natural history of fibrotic lung disease associated with rheumatoid arthritis remains largely undefined. It is the intent of this clinical protocol to (1) estimate the prevalence of pulmonary fibrosis in individuals with rheumatoid arthritis, (2) define the natural history of pulmonary fibrosis in patients with rheumatoid arthritis, (3) e...

Gender

All

Eligibility criteria

  • INCLUSION CRITERIA:
  • Non-smokers (never smoked or no smoking within the previous 2 years) who are 21 years of age or older with any of the following:
  • Rheumatoid arthritis with biopsy-proven pulmonary fibrosis or;
  • Rheumatoid arthritis only, or;
  • Biopsy-proven idiopathic pulmonary fibrosis.
  • EXCLUSION CRITERIA:
  • Forced expiratory volume in one second (FEV1) less than 1L.
  • Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium).
  • Chronic cardiopulmonary disorders other than pulmonary fibrosis.
  • Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
  • Non-rheumatoid arthritis.
  • Viral infections associated with pulmonary fibrosis (e.g., hepatitis B, hepatitis C, human immunodeficiency virus).
  • Uncorrectable bleeding diathesis.
  • Pregnancy or lactation.

Attachments

readout_NCT00001876_2023-12-10.pdf

4.5 MB

NCT00001876_study_protocol.pdf

4.5 MB

About company

The National Institute of Allergy and Infectious Diseases (NIAID, /ˈnaɪ.æd/) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases.

Contacts

JC

Jennifer Cobb

Immunology at National Institute of Allergy and Infectious Diseases (NIAID)

Locations

Bethesda, Maryland, United States

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Ongoing

Reviews (48)

4.6

All reviews come from applied patients

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Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Michael Foster
20 September 2023

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Dries Vincent
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

Leslie Alexander
20 September 2023

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum?

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