Search / Trial NCT00001876

Lung Disease Associated With Rheumatoid Arthritis

Launched by NATIONAL HUMAN GENOME RESEARCH INSTITUTE (NHGRI) · Nov 3, 1999

Trial Information

Current as of December 06, 2024

Completed

Keywords

Interstitial Lung Disease Collagen Vascular Disease Extracellular Matrix Pulmonary Function Dtpa Lung Clearance Scan Natural History

ClinConnect Summary

Pulmonary fibrosis is an extra-articular manifestation of rheumatoid arthritis whose etiology remains uncertain. Although the clinical course of many individuals with this disorder can mimic that observed in patients with idiopathic pulmonary fibrosis, the natural history of fibrotic lung disease associated with rheumatoid arthritis remains largely undefined. It is the intent of this clinical protocol to (1) estimate the prevalence of pulmonary fibrosis in individuals with rheumatoid arthritis, (2) define the natural history of pulmonary fibrosis in patients with rheumatoid arthritis, (3) e...

Gender

ALL

Eligibility criteria

  • * INCLUSION CRITERIA:
  • Non-smokers (never smoked or no smoking within the previous 2 years) who are 21 years of age or older with any of the following:
  • Rheumatoid arthritis with biopsy-proven pulmonary fibrosis or;
  • Rheumatoid arthritis only, or;
  • Biopsy-proven idiopathic pulmonary fibrosis.
  • EXCLUSION CRITERIA:
  • Forced expiratory volume in one second (FEV1) less than 1L.
  • Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium).
  • Chronic cardiopulmonary disorders other than pulmonary fibrosis.
  • Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
  • Non-rheumatoid arthritis.
  • Viral infections associated with pulmonary fibrosis (e.g., hepatitis B, hepatitis C, human immunodeficiency virus).
  • Uncorrectable bleeding diathesis.
  • Pregnancy or lactation.

Trial Officials

Bernadette R Gochuico, M.D.

Principal Investigator

National Human Genome Research Institute (NHGRI)

About National Human Genome Research Institute (Nhgri)

The National Human Genome Research Institute (NHGRI) is a prominent research organization within the National Institutes of Health (NIH) dedicated to advancing the field of genomics and its applications in health and medicine. NHGRI sponsors and conducts a wide range of clinical trials aimed at understanding the genetic basis of diseases, developing innovative genomic technologies, and translating genomic research into clinical practice. With a commitment to ethical research and collaboration, NHGRI plays a pivotal role in shaping the future of personalized medicine and improving patient outcomes through genomic discoveries.

Locations

Bethesda, Maryland, United States

Bethesda, Maryland, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0

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