Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis
Launched by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) · Nov 3, 1999
Trial Information
Current as of May 09, 2025
Completed
Keywords
ClinConnect Summary
Pulmonary fibrosis that develops within a subpopulation of patients with rheumatoid arthritis is a disorder of unknown etiology. Although previous reports suggest that some individuals with rheumatoid arthritis have a genetic predisposition to the development of fibrotic lung disease, genetic factors have not been clearly identified. It is the intent of this clinical protocol to identify genetic polymorphisms in individuals with pulmonary fibrosis and rheumatoid arthritis.
Gender
ALL
Eligibility criteria
- * INCLUSION CRITERIA:
- Individuals 21 years of age or older with any of the following:
- • RA (based on 1987 American College of Rheumatology Revised Criteria for the Classification of RA) with PF (biopsy-proven), or
- • RA-only, or
- • Biopsy-proven idiopathic PF-only, or
- • Healthy research volunteers.
- EXCLUSION CRITERIA:
- Individuals with any of the following:
- • Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium).
- • Chronic pulmonary disorders other than pulmonary fibrosis.
- • Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease).
- • Non-rheumatoid arthritis.
- • Viral infections associated with PF (e.g., hepatitis B, hepatitis C, human immunodeficiency virus).
- • Pregnancy.
About National Heart, Lung, And Blood Institute (Nhlbi)
The National Heart, Lung, and Blood Institute (NHLBI) is a leading component of the National Institutes of Health (NIH), dedicated to advancing research and clinical trials focused on cardiovascular, pulmonary, and hematologic diseases. With a mission to improve public health through innovative research, the NHLBI supports a wide range of studies aimed at understanding, preventing, and treating heart and lung conditions. By collaborating with academic institutions, healthcare providers, and patient communities, the NHLBI strives to translate scientific discoveries into effective clinical practices, ultimately enhancing the quality of life for individuals affected by these critical health issues.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bethesda, Maryland, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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