The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before

Launched by FISONS · Aug 30, 2001

Keywords

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Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• Concurrent Medication:
• Allowed:
• • Zidovudine (AZT).
• • Exclusion Criteria
• Co-existing Condition:
• Patients with the following are excluded:
• * Requiring ongoing active therapy for an opportunistic infection (O.I.) at time of entry or those with either of the following AIDS-defining O.I.'s prior to entry:
• • Toxoplasmosis.
• • Cryptococcosis.
• • Transfusion dependent (requiring blood transfusion more than once per month). The last transfusion cannot have been given within 7 days of study entry.
• • Pulmonary Kaposi's sarcoma (KS).
• • Asthma requiring medication.
• • Active therapy for tuberculosis.
• Concurrent Medication:
• Excluded:
• • Active therapy for tuberculosis.
• Patients with the following are excluded:
• * Requiring ongoing active therapy for an opportunistic infection (O.I.) at time of entry or those with either of the following AIDS-defining O.I.'s prior to entry:
• • Toxoplasmosis.
• • Cryptococcosis.
• • Transfusion dependent (requiring blood transfusion more than once per month). The last transfusion cannot have been given within 7 days of study entry.
• • Pulmonary Kaposi's sarcoma (KS).
• • Unwilling to sign informed consent.
• • Cannot cooperate with study procedures.
• • Asthma requiring medication.
• Prior Medication:
• Excluded within 30 days of study entry:
• • Antiretrovirals other than zidovudine (AZT).
• • Immunomodulating agents.
• • Corticosteroids.
• Patients must:
• • Have AIDS and recovered from their first episode of cytologically or histologically proven Pneumocystis carinii pneumonia (PCP).
• • Be at least 2 weeks and no more than 24 weeks status post therapy for acute PCP.
• • Have positive antibody to HIV by any federally licensed ELISA test kit, or confirmed Western blot test.
• • Have adequate pulmonary function (vital capacity = or \> 80 percent of predicted; forced expiratory volume (FEV), 1 s = or \> 65 percent of total FEV; and corrected pulmonary diffusion capacity \> 60 percent of predicted).
• • Free of acute medical problems.
• • Active substance abuse.