Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors

Launched by MAYO CLINIC · Jan 26, 2003

Keywords

ClinConnect Summary

OBJECTIVES:

* Determine the response rate of patients with newly diagnosed CNS germ cell tumors treated with cisplatin and etoposide.
* Determine the survival of patients with CNS germ cell tumors treated with cisplatin and etoposide followed by cranial radiotherapy.
* Determine endocrine and cognitive function in these patients before and after receiving this regimen.

OUTLINE: Patients are stratified by histology (germinoma vs nongerminoma).

Patients receive cisplatin IV over 4 hours followed by etoposide IV over 30-60 minutes on days 1-5. Treatment continues every 3 weeks for 4 courses...

Gender

ALL

Eligibility criteria

• DISEASE CHARACTERISTICS:
• * Histologically proven CNS germ cell tumor of 1 of the following subtypes:
• • CNS germinoma
• • Immature teratoma
• • Embryonal cell carcinoma
• • Yolk sac tumor
• • Endodermal sinus tumor
• • Choriocarcinoma OR
• • Pineal or suprasellar mass associated with elevated CSF alpha fetoprotein or beta-human chorionic gonadotropin allowed
• • Patients 18 years and over with localized pure germinomas ineligible
• • Evaluable CT or MRI of brain and/or spinal cord required
• PATIENT CHARACTERISTICS:
• Age:
• • 3 and over
• Hematopoietic:
• * Age 18 and over:
• • WBC at least 4,000/mm\^3
• • Platelet count at least 100,000/mm\^3
• * Under age 18:
• • Absolute neutrophil count at least 1,000/mm\^3
• • Platelet count at least 100,000/mm\^3
• Hepatic:
• • Not specified
• Renal:
• • Creatinine no greater than 0.3 mg/dL above upper limit of normal for age
• Other:
• • No uncontrolled infection
• • Not pregnant or nursing
• • Negative pregnancy test
• • Fertile patients must use effective contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• • Not specified
• Chemotherapy:
• • No prior chemotherapy for CNS germ cell tumor
• Endocrine therapy:
• • Concurrent corticosteroids allowed except as antiemetics
• Radiotherapy:
• • No prior cranial or spinal radiotherapy
• Surgery:
• • Not specified

Trial Officials