Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia

Launched by EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER - EORTC · Jan 26, 2003

Keywords

ClinConnect Summary

OBJECTIVES:

* Compare the remission induction, toxicity, and duration of remission in patients with newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma treated with prednisone vs dexamethasone plus cyclophosphamide, daunorubicin, and vincristine as induction.
* Compare the survival and disease-free survival of patients treated with autologous bone marrow transplantation (BMT) followed by low- or high-intensity maintenance chemotherapy with cranial irradiation after consolidation.
* Determine the relative and disease-free survival of patients treated with autologous or al...

Gender

ALL

Eligibility criteria

• DISEASE CHARACTERISTICS:
• • Newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma with more than 30% blasts in bone marrow
• PATIENT CHARACTERISTICS:
• Age:
• • 15 to 60
• Performance status:
• • Not specified
• Life expectancy:
• • Not specified
• Hematopoietic:
• • See Disease Characteristics
• Hepatic:
• • Bilirubin less than 2 mg/dL (unless elevation due to leukemic involvement of liver)
• Renal:
• • Creatinine less than 2 mg/dL (unless elevation due to leukemic involvement of kidneys)
• Cardiovascular:
• • No severe cardiac disease
• Pulmonary:
• • No severe pulmonary disease
• Other:
• • No severe neurologic or metabolic disease
• • HIV negative (if tested)
• • No other prior malignancy except nonmelanomatous skin cancer, stage I cervical carcinoma, or other curatively treated malignancy
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• • No prior biologic therapy
• Chemotherapy:
• • No prior chemotherapy
• Endocrine therapy:
• • No prior endocrine therapy
• Radiotherapy:
• • No prior radiotherapy
• Surgery:
• • No prior surgery

Trial Officials