Study of Proteins Associated With Complex Regional Pain Syndrome

Launched by NATIONAL INSTITUTE OF NURSING RESEARCH (NINR) · Apr 17, 2002

Keywords

ClinConnect Summary

The etiology of Complex Regional Pain Syndrome (CRPS) is unknown but a patient typically presents with a triad of clinical findings: sensory abnormalities, perfusion abnormalities and alterations in motor function. Since some of these findings are seen in the other disease states, the diagnosis is often not clear. A response to a sympathetic ganglion block (stellate or lumbar) is also suggestive of the disorder. However, there is no definitive diagnostic test for CRPS. Experience has shown that early aggressive treatment improves the prognosis. Therefore, tests that facilitate the early dia...

Gender

ALL

Eligibility criteria

• • INCLUSION CRITERIA
• • Male or female patients referred by their physician with the diagnosis of CRPS criteria as outlined by Stanton-Hicks et al.
• • OR
• • Healthy volunteers will be screened according to the eligibility criteria as specified in the appendix (see Healthy Subject Eligibility).
• • Age restrictions: Patients and volunteers must be (Bullet)18 years of age at the time of enrollment. There is no upper limit for age of inclusion.
• • Good general health (other disease states could may confound the results see exclusion criteria)
• • Willing to have blood drawn
• • Willing to have behavioral measures
• • Willing to provide a directed medical history
• • There is expected to be a greater number of females than males being recruited to this study since there is a much higher occurrence of CRPS in women. Additionally, it is expected to be equal across all ethnic groups. However, we do not anticipate requiring any special recruiting strategies for specific gender or ethnic groups.
• • EXCLUSION CRITERIA
• • Contraindication to blood screening
• • Advanced disease other than the CRPS (cardiovascular, liver, kidney disease ASA III or above excluding CRPS) that may cause a theoretical inclusion of samples resulting in confounding results.
• • Pregnant and lactating women.
• • No exclusions will be made based on race, gender, or religion.