Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)

Launched by FREDERICK SCHMITT · Jun 26, 2002

Keywords

ClinConnect Summary

Studies show that increased oxidative stress (from excess free radicals) may damage brain cells and is linked with Alzheimer's disease (AD). Many studies show increased oxidation of brain lipids (fats), proteins, carbohydrates (sugars) and DNA in AD. Although the causes of AD are not known, it is believed that oxidative stress is part of what damages brain cells in AD and probably other brain diseases. Animal and tissue culture studies of vitamin E and selenium suggest that they can protect brain cells from damage. This research study is being done to see how safe and effective vitamin E an...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Participating in SELECT Prevention study;
• • 62 years or older if other ethnic origin, or 60 years or older if African-American or Hispanic;
• • General good health with no neurological or psychiatric illness.
• Exclusion Criteria:
• The SELECT doctors or staff will review the PREADVISE applicants' medical history and drugs to verify that they have no condition(s) that would exclude them from this study. The participant must not have any of the following neurological conditions based on self report (were told by a physician):
• • Alzheimer's disease, or any other form of dementia such as Pick's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, significant cognitive and motor impairment from a stroke or corticobasal degeneration;
• • Huntington's disease, epilepsy, Parkinson's disease, brain tumor, multiple sclerosis, manic-depressive disorder, or schizophrenia;
• • The participant must not have had a head injury with prolonged loss of consciousness (over 30 minutes) within the past five years;
• • The participant must not have a current alcohol or substance abuse diagnosis, or must have been treatment free for the past 24 months;
• • The participant must not have had a diagnosis of depression or anxiety disorder in the past 4 months and must not currently be under treatment for depression or anxiety disorder. \[A participant who was previously diagnosed with depression or anxiety disorder but completed treatment more than four months ago is eligible.\];
• • The participant must not currently use of any of the following medications: Aricept, Cognex, Exelon, Reminyl, or Hydergine;
• • The participant must not have blindness, deafness, language difficulties or any other disability that may prevent completion of the memory screen.