Genetic Study of Young Patients With Colorectal Cancer
Launched by ALLIANCE FOR CLINICAL TRIALS IN ONCOLOGY · Jan 26, 2003
Trial Information
Current as of April 27, 2025
Completed
Keywords
ClinConnect Summary
OBJECTIVES:
* Evaluate the prognostic significance (e.g., overall survival) of microsatellite instability (MSI) status in patients with early age-of-onset stage I-III colorectal cancer, assuming the presence of a quantitative interaction between MSI status and family history of cancer.
* Evaluate the development of metachronous neoplasms in this patient population.
* Evaluate the histologic features and genetic changes associated with hereditary nonpolyposis colorectal cancer in this patient population.
OUTLINE: This is a multicenter study. Patients are stratified according to family hist...
Gender
ALL
Eligibility criteria
- DISEASE CHARACTERISTICS:
- • Diagnosis of stage I-III adenocarcinoma of the colon or rectum
- • Must have undergone an initial curative resection within the past year
- • No colon or rectal cancer resection that does not allow for definitive T or N staging
- • No initial post-surgical surveillance colonoscopy prior to study entry
- • Must have a pathology specimen, with representative normal and tumor tissues, available for submission to the ACOSOG Central Specimen Bank prior to study entry
- • No personal or family history of familial adenomatous polyposis
- • No recurrent colorectal cancer
- PATIENT CHARACTERISTICS:
- • Age
- • 18 to 49 at first diagnosis
- • Other
- • Must be willing to provide a family cancer history to the study team and continue with follow-up colonoscopic surveillance
- • No other malignancy within the past 5 years except completely resected cervical cancer or nonmelanoma skin cancer
- • No evidence of recurrence of other prior malignancy
- PRIOR CONCURRENT THERAPY:
- • Radiotherapy
- • No prior pelvic radiotherapy for rectal cancer
- • No concurrent preoperative pelvic radiotherapy for rectal cancer
- • Surgery
- • See Disease Characteristics
About Alliance For Clinical Trials In Oncology
The Alliance for Clinical Trials in Oncology is a prominent cooperative group dedicated to conducting high-quality, innovative clinical research aimed at improving cancer treatment and patient outcomes. Comprising a diverse network of institutions and investigators, the Alliance focuses on developing and implementing clinical trials that evaluate new therapies, treatment combinations, and prevention strategies across various cancer types. By fostering collaboration among oncologists, researchers, and healthcare professionals, the Alliance aims to accelerate the translation of scientific discoveries into effective clinical practices, ultimately enhancing the standard of care for cancer patients.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
New York, New York, United States
Maywood, Illinois, United States
Tampa, Florida, United States
Minneapolis, Minnesota, United States
Durham, North Carolina, United States
Abington, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Milwaukee, Wisconsin, United States
Tampa, Florida, United States
Chicago, Illinois, United States
Indianapolis, Indiana, United States
Winston Salem, North Carolina, United States
Arlington Heights, Illinois, United States
Pittsburgh, Pennsylvania, United States
Spokane, Washington, United States
Madison, Wisconsin, United States
Toronto, Ontario, Canada
Iowa City, Iowa, United States
Columbia, Missouri, United States
Saint Louis, Missouri, United States
Abington, Pennsylvania, United States
Cleveland, Ohio, United States
Shreveport, Louisiana, United States
Salt Lake City, Utah, United States
Pittsburgh, Pennsylvania, United States
New Orleans, Louisiana, United States
Falls Church, Virginia, United States
San Francisco, California, United States
Cleveland, Ohio, United States
Philadelphia, Pennsylvania, United States
Madison, Wisconsin, United States
Mobile, Alabama, United States
Duarte, California, United States
San Francisco, California, United States
Tulsa, Oklahoma, United States
Des Moines, Iowa, United States
Charlotte, North Carolina, United States
Milwaukee, Wisconsin, United States
Spokane, Washington, United States
Richmond, Virginia, United States
Burlington, Massachusetts, United States
Omaha, Nebraska, United States
Thunder Bay, Ontario, Canada
Rochester, New York, United States
Mobile, Alabama, United States
Baltimore, Maryland, United States
Worcester, Massachusetts, United States
Houston, Texas, United States
Iowa City, Iowa, United States
Maywood, Illinois, United States
Burlington, Vermont, United States
Chicago, Illinois, United States
Dallas, Texas, United States
Pittsburgh, Pennsylvania, United States
Chicago, Illinois, United States
Winston Salem, North Carolina, United States
Fort Lauderdale, Florida, United States
Spokane, Washington, United States
Omaha, Nebraska, United States
Philadelphia, Pennsylvania, United States
Clearwater, Florida, United States
Lexington, Kentucky, United States
Nashville, Tennessee, United States
Houston, Texas, United States
Milwaukee, Wisconsin, United States
Mobile, Alabama, United States
Colton, California, United States
Gainesville, Georgia, United States
Flint, Michigan, United States
Memphis, Tennessee, United States
Fairfax, Virginia, United States
Aurora, Illinois, United States
Dallas, Texas, United States
Baltimore, Maryland, United States
Pittsburgh, Pennsylvania, United States
Indianapolis, Indiana, United States
Falls Church, Virginia, United States
Akron, Ohio, United States
Durham, North Carolina, United States
Gainesville, Florida, United States
Dallas, Texas, United States
Charlotte, North Carolina, United States
Spokane, Washington, United States
Nashville, Tennessee, United States
Tupelo, Mississippi, United States
Oklahoma City, Oklahoma, United States
Chattanooga, Tennessee, United States
Spokane, Washington, United States
Spokane, Washington, United States
Appleton, Wisconsin, United States
Appleton, Wisconsin, United States
Falls Church, Virginia, United States
Patients applied
Trial Officials
Jose G. Guillem, MD
Study Chair
Memorial Sloan Kettering Cancer Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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