Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Sep 9, 2005

Keywords

ClinConnect Summary

Hypertension affects 20% to 25% of adult population. Most patients are diagnosed as having essential or primary hypertension. Up to 10% to 15 % have an identifiable cause and many of those have an adrenal basis \[Miroslava H. et al., 2002\]. The tissue kallikrein-kinin (KKS) and renin-angiotension-aldosterone system (RAAS) had been implicated in regulating blood pressure and electrolyte homeostasis. Recent studies in humans indicate that the vasodilator tissue KKS, the counterpart of the tissue RAAS, is also expressed in the adrenal gland. The adrenal gland regulates sodium and water excret...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with hypertension admitted for the diagnosis of primary aldosteronism
• Exclusion Criteria:
• • Pregnant or lactating women. (Pre-menopause women, capable of bearing children will undergo pregnancy test), hypertension without discontinuous b-blocker, ACEI or ARB for more than 10 days.