Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF).

Launched by THE GEORGE INSTITUTE · Sep 14, 2005

Keywords

ClinConnect Summary

Study Title - Multicentre, Unblinded, Randomised, Controlled Trial to assess the effect of Augmented vs. Normal Continuous Renal Replacement Therapy (CRRT) on 90-day all-cause mortality of Intensive Care Unit Patients with Severe Acute Renal Failure (ARF).

Clinical Phase - IV

Study Rationale - This study will provide high quality evidence from a mulit-center randomised controlled trial about the comparative effects of different targets for CRRT dose in patients with ARF treated in the Australasian intensive care setting. This evidence will have direct relevance to decisions about the care...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The treating clinician believes that the patient requires CRRT for acute renal failure.
• • 2. The clinician is uncertain about the balance of benefits and risks likely to be conferred by treatment with higher intensity or lower intensity CRRT.
• • 3. The treating clinicians anticipate treating the patient with CRRT for at least 72 hours.
• • 4. Informed consent has been obtained
• 5. The patient fulfils ONE of the following clinical criteria for initiating CRRT:
• • Oliguria (urine output \< 100ml/6hr) that has been unresponsive to fluid resuscitation measures.
• • Hyperkalemia (\[K+\] \> 6.5 mmol/L).
• • Severe acidemia (pH \< 7.2).
• • Urea \> 25 mmol/liter.
• • Creatinine \>300 micromol/L in the setting of ARF.
• • Clinically significant organ oedema in the setting of ARF (eg: lung).
• Exclusion Criteria:
• • 1. Patient age is \<18 years.
• • 2. Death is imminent (\<24 hours).
• • 3. There is a strong likelihood that the study treatment would not be continued in accordance with the study protocol.
• • 4. The patient has been treated with CRRT or other dialysis previously during the same hospital admission.
• • 5. The patient was on maintenance dialysis prior to the current hospitalisation.
• • 6. The patient's body weight is \<60 kg or \>100kg.
• • 7. Any other major illness that, in the investigator's judgment, will substantially increase the risk associated with the subject's participation in this study.