Desmopressin Response in the Young

Launched by FERRING PHARMACEUTICALS · Sep 29, 2005

Keywords

ClinConnect Summary

Primary nocturnal enuresis (PNE), or bedwetting, is a common childhood urological disease. Factors contributing to nocturnal enuresis include nocturnal polyuria due to, at least in part, a relative deficiency of antidiuretic hormone arginine vasopressin (AVP) which has been supported by the finding that some enuretic children lack a nocturnal increase in endogenous AVP secretion. Desmopressin, a synthetic, structural analogue of AVP, selective for V2-receptors and with a longer half life than the natural hormone, has been found to be especially beneficial in PNE subjects with nocturnal poly...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children and adolescents (age 5-16 years) with diagnosed primary monosymptomatic nocturnal enuresis.
• • A minimum of 3 wet nights per week in the 2-week screening period without treatment.
• Exclusion Criteria:
• • Presence or a history of organic urological disease, diurnal urinary incontinence, polydipsia, diabetes insipidus, ongoing urinary tract infection, clinically significant renal, hepatic, gastrointestinal, pulmonary, cardiovascular, endocrinological or neurological disease that would interfere with evaluation.
• • Ongoing systemic antibiotic use, use of diuretics or any drugs affecting urinary concentration, or medical treatment for hyperactivity.
• • Usage of any experimental drug or device during 30 days before study entry.

Trial Officials