Survival Of Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Launched by GLAXOSMITHKLINE · Dec 21, 2005
Trial Information
Current as of May 28, 2025
Completed
Keywords
ClinConnect Summary
A multicenter, randomized, double-blind, parallel group, placebo controlled study to investigate the effects of salmeterol/fluticasone 50/500mcg bd, salmeterol 50mcg bd, and fluticasone 500mcg bd, all delivered via the DISKUS/ACCUHALER inhaler, on the survival of subjects with chronic obstructive pulmonary disease over 3 years of treatment.
Gender
ALL
Eligibility criteria
- Inclusion criteria:
- • Patients with COPD and FEV1 \<60% of predicted normal and baseline (pre-bronchodilator) FEV1/FVC ratio \<70%.
- • Current or ex-smokers with a smoking history of at least 10 pack-years.
- Exclusion criteria:
- • Diagnosis of other respiratory disorders (including asthma).
- • Requirement for long term oxygen therapy.
About Glaxosmithkline
GlaxoSmithKline (GSK) is a global healthcare company dedicated to improving the quality of human life by enabling people to do more, feel better, and live longer. With a strong focus on research and development, GSK specializes in pharmaceuticals, vaccines, and consumer health products. The company is committed to advancing innovative therapies and preventive measures across various therapeutic areas, including respiratory, oncology, immunology, and infectious diseases. GSK's collaborative approach and rigorous clinical trial processes underscore its dedication to delivering safe and effective healthcare solutions that meet the needs of patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Decatur, Georgia, United States
Tampa, Florida, United States
Barcelona, , Spain
Madrid, , Spain
Shreveport, Louisiana, United States
Minneapolis, Minnesota, United States
Toledo, Ohio, United States
La Crosse, Wisconsin, United States
Atlanta, Georgia, United States
Kansas City, Missouri, United States
Tallinn, , Estonia
Tartu, , Estonia
Albany, New York, United States
Charlotte, North Carolina, United States
Oklahoma City, Oklahoma, United States
Spartanburg, South Carolina, United States
Salt Lake City, Utah, United States
Valparaiso, Valparaíso, Chile
Mineola, New York, United States
Morristown, Tennessee, United States
Fort Lauderdale, Florida, United States
Ferrara, Emilia Romagna, Italy
Manchester, Lancashire, United Kingdom
Phoenix, Arizona, United States
Los Angeles, California, United States
New York, New York, United States
Adelaide, South Australia, Australia
Melbourne, Victoria, Australia
Sainte Foy, Quebec, Canada
Xian, Shaanxi, China
Wangfujing, Beijing, , China
Helsinki, , Finland
Heraklion, Crete, , Greece
Budapest, , Hungary
Heerlen, , Netherlands
Singapore, , Singapore
Barakaldo (Vizcaya), , Spain
Tau Yuan County, , Taiwan
Pittsburgh, Pennsylvania, United States
Scottsdale, Arizona, United States
Fort Collins, Colorado, United States
St. Charles, Missouri, United States
Mobile, Alabama, United States
San Diego, California, United States
Walnut Creek, California, United States
Longmont, Colorado, United States
Clearwater, Florida, United States
Tamarac, Florida, United States
West Palm Beach, Florida, United States
Roswell, Georgia, United States
Coeur D'alene, Idaho, United States
Chicago, Illinois, United States
Lafayette, Louisiana, United States
St. Joseph, Michigan, United States
Jackson, Mississippi, United States
Billings, Montana, United States
Lebanon, New Hampshire, United States
Winston Salem, North Carolina, United States
Cincinnati, Ohio, United States
Cranston, Rhode Island, United States
Greer, South Carolina, United States
Simpsonville, South Carolina, United States
Houston, Texas, United States
Virginia Beach, Virginia, United States
Spokane, Washington, United States
Rio De Janeiro, , Brazil
Montreal, Quebec, Canada
Quebec, , Canada
Zagreb, , Croatia
Caen Cedex, , France
Cholet, , France
Larisa, , Greece
Thessaloniki, , Greece
Mexico, D.F., , Mexico
Mexico, , Mexico
Arnhem, , Netherlands
Breda, , Netherlands
Ede, , Netherlands
Hengelo, , Netherlands
Roosendaal, , Netherlands
Cape Town, , South Africa
Exeter, Devon, United Kingdom
, ,
Chapel Hill, North Carolina, United States
Albuquerque, New Mexico, United States
Wichita, Kansas, United States
Lexington, Kentucky, United States
Sherbrooke, Quebec, Canada
Heidelberg, Victoria, Australia
Encinitas, California, United States
St. Louis, Missouri, United States
Jacksonville, Florida, United States
Sarasota, Florida, United States
Augusta, Georgia, United States
Auburn, Maine, United States
Baltimore, Maryland, United States
Downington, Pennsylvania, United States
Bristol, Tennessee, United States
Calgary, Alberta, Canada
Louisville, Kentucky, United States
East Providence, Rhode Island, United States
Birmingham, Alabama, United States
Zephyrhills, Florida, United States
Blue Ridge, Georgia, United States
Rome, Georgia, United States
Peoria, Illinois, United States
Chesterfield, Missouri, United States
Great Neck, New York, United States
Wilmington, North Carolina, United States
Johnson City, Tennessee, United States
Kingsport, Tennessee, United States
San Antonio, Texas, United States
Chesapeake, Virginia, United States
Wheat Ridge, Colorado, United States
Longwood, Florida, United States
Jefferson City, Missouri, United States
High Point, North Carolina, United States
Medford, Oregon, United States
Riverside, California, United States
Brandon, Florida, United States
Dubuque, Iowa, United States
Fullerton, California, United States
Camperdown, New South Wales, Australia
Wellington, , New Zealand
Allentown, Pennsylvania, United States
Vienna, , Austria
Alicante, , Spain
Cadiz, , Spain
Vigo/Pontevedra, , Spain
Jasper, Alabama, United States
Rancho Mirage, California, United States
Nedlands, Western Australia, Australia
Saint John's, Newfoundland And Labrador, Canada
Hradec Kralove, , Czech Republic
Utrecht, , Netherlands
Auckland, , New Zealand
Lahore, , Pakistan
Altamonte Springs, Florida, United States
Greenville, South Carolina, United States
Guadalajara, Jalisco, Mexico
Denver, Colorado, United States
Stamford, Connecticut, United States
Atlantis, Florida, United States
Bay Pines, Florida, United States
North Chicago, Illinois, United States
Bellingham, Washington, United States
Huntington, West Virginia, United States
Saint John, New Brunswick, Canada
Lappeenranta, , Finland
Mikkeli, , Finland
Marseille Cedex 20, , France
Kowloon, , Hong Kong
Kubang Kerian, , Malaysia
Tauranga, , New Zealand
Bucharest, , Romania
La Coruña, , Spain
Bangkok, , Thailand
Chiangmai, , Thailand
Tanjong Bungah, , Malaysia
Marietta, Georgia, United States
Pleven, , Bulgaria
Quezon City, , Philippines
Guadalajara, , Spain
Santiago De Compostela, , Spain
Vizcaya, , Spain
Tainan, , Taiwan
Taipei, , Taiwan
San Francisco, California, United States
Newark, New Jersey, United States
Ponce, , Puerto Rico
Madison, Wisconsin, United States
Mississauga, Ontario, Canada
Bad Segeberg, Schleswig Holstein, Germany
Göteborg, , Sweden
Kwun Tong, , Hong Kong
Manila, , Philippines
Edmonton, Alberta, Canada
La Plata, Buenos Aires, Argentina
Praha 8, , Czech Republic
Stockton, California, United States
Hartford, Connecticut, United States
Sunset, Louisiana, United States
Elizabeth City, North Carolina, United States
Richmond, Virginia, United States
Corsicana, Texas, United States
South Bend, Indiana, United States
Summit, New Jersey, United States
Lake Oswego, Oregon, United States
Berkeley, California, United States
Long Beach, California, United States
Vista, California, United States
Largo, Florida, United States
Boston, Massachusetts, United States
Cadillac, Michigan, United States
Las Vegas, Nevada, United States
Bronxville, New York, United States
Erie, Pennsylvania, United States
Sepuldeva, California, United States
Traverse City, Michigan, United States
São Paulo, , Brazil
Cartagena, , Spain
Banska Bystrica, , Slovakia
Varna, , Bulgaria
Kavala, , Greece
Skien, , Norway
Valencia, , Spain
Thunder Bay, Ontario, Canada
Burbank, California, United States
Bialystok, , Poland
Kassel, Hessen, Germany
Iasi, , Romania
Praha 5, , Czech Republic
Pori, , Finland
East Orange, New Jersey, United States
Wels, , Austria
Zabrze, , Poland
Maurepas, , France
Saint Quentin, , France
Kobenhavn Nv, , Denmark
Dordrecht, , Netherlands
Liverpool, Lancashire, United Kingdom
London, , United Kingdom
Champaign, Illinois, United States
Omaha, Nebraska, United States
Miami, Florida, United States
Palm Springs, Florida, United States
Pisa, Toscana, Italy
Bergen, , Norway
N. Efkarpia, Thessaloniki, , Greece
Franklin, Ohio, United States
Zwolle, , Netherlands
Charleston, South Carolina, United States
Nantes, , France
Porto Alegre, Rio Grande Do Sul, Brazil
Szolnok, , Hungary
Hamilton, , New Zealand
Toorak Gardens, South Australia, Australia
Geelong, Victoria, Australia
Kaohsiung, , Taiwan
Beijing, , China
Lomme, , France
Hvidovre, , Denmark
Hines, Illinois, United States
Schwetzingen, Baden Wuerttemberg, Germany
Berlin, , Germany
Grenoble, , France
Kaunas, , Lithuania
Ozark, Alabama, United States
Fresno, California, United States
San Luis Obispo, California, United States
Sunnyvale, California, United States
Sylmar, California, United States
Arvada, Colorado, United States
Loveland, Colorado, United States
Pueblo, Colorado, United States
Loxahatchee, Florida, United States
Pace, Florida, United States
Pensacola, Florida, United States
Swansea, Massachusetts, United States
Livonia, Michigan, United States
Edina, Minnesota, United States
Gilford, New Hampshire, United States
New Brunswick, New Jersey, United States
Trenton, New Jersey, United States
Brooklyn, New York, United States
Buffalo, New York, United States
Cleveland, Ohio, United States
Portland, Oregon, United States
Doylestown, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Ridley Park, Pennsylvania, United States
Milan, Tennessee, United States
Fredericksburg, Virginia, United States
Roanoke, Virginia, United States
Vicente López, Buenos Aires, Argentina
Buenos Aires, , Argentina
Bankstown, New South Wales, Australia
North Gosford, New South Wales, Australia
Frankston, Victoria, Australia
Bruxelles, , Belgium
Namur, , Belgium
Oostende, , Belgium
Orp Jauche, , Belgium
Veurne, , Belgium
Santo Andre, São Paulo, Brazil
Russe, , Bulgaria
Sofia, , Bulgaria
Maple Ridge, British Columbia, Canada
Scarborough, Ontario, Canada
Toronto, Ontario, Canada
Windsor, Ontario, Canada
Temuco, Región De La Araucania, Chile
Santiago, Región Metro De Santiago, Chile
Guangzhou, Guangdong, China
Nanjing, Jiangsu, China
Shenyang, Liaoning, China
Chongqing, , China
Shanghai, , China
Jaromer, , Czech Republic
Ostrava Fifejdy, , Czech Republic
Tabor, , Czech Republic
Aarhus C, , Denmark
Silkenborg, , Denmark
Kohtal Jdrve, , Estonia
Kinkomaa, , Finland
Lohja, , Finland
Oulainen, , Finland
Vantaa, , Finland
Annonay, , France
Avrille, , France
Bethune Cedex, , France
Bois Guillaume, , France
Chamalières, , France
Corbeil Essonne, , France
Ferolles Attilly, , France
Lille, , France
Meaux, , France
Nimes, , France
Paris Cedex 04, , France
Tarbes Cedex 09, , France
Toulouse Cedex 9, , France
Tours Cedex 1, , France
Verdun, , France
Darmstadt, Hessen, Germany
Hannover, Niedersachsen, Germany
Bielefeld, Nordrhein Westfalen, Germany
Athens, , Greece
Chania, Crete, , Greece
Maroussi, Athens, , Greece
Papagos/Athens, , Greece
Patra, , Greece
Aberdeen, , Hong Kong
Lai Chi Kok, , Hong Kong
Tai Po,, , Hong Kong
Cegléd, , Hungary
Dunaujvaros, , Hungary
Tatabanya, , Hungary
Törökbálint, , Hungary
Fossvogur. Reykjavic, , Iceland
Reykjavik, , Iceland
Brescia, Lombardia, Italy
Milano, Lombardia, Italy
Sesto San Giovanni (Mi), Lombardia, Italy
Tradate (Va), Lombardia, Italy
Bussolengo (Vr), Veneto, Italy
Riga, , Latvia
Kuala Lumpur, , Malaysia
Kuching, , Malaysia
Bilthoven, , Netherlands
Hoofddorp, , Netherlands
Terneuzen, , Netherlands
Wellington South, , New Zealand
Alesund, , Norway
Bardufoss, , Norway
Bodo, , Norway
Harstad, , Norway
Oslo, , Norway
Sandvika, , Norway
Tonsberg, , Norway
Trondheim, , Norway
Volda, , Norway
Cebu City, , Philippines
Katowice, , Poland
Warszawa, , Poland
Wroclaw, , Poland
Brasov, , Romania
Moscow, , Russian Federation
Kralovsky Chlmec, , Slovakia
Nove Zamky, , Slovakia
Partizanske, , Slovakia
Durban, Kwazulu Natal, South Africa
Mowbray, , South Africa
Pretoria, , South Africa
Elda, , Spain
Orihuela/Alicante, , Spain
Boden, , Sweden
Eksjö, , Sweden
Helsingborg, , Sweden
Lidköping, , Sweden
Trollhättan, , Sweden
Taichung, , Taiwan
Kiev, , Ukraine
Bristol, Gloucestershire, United Kingdom
Newcastle Upon Tyne, Northumberland, United Kingdom
Headington, Oxfordshire, United Kingdom
Patients applied
Trial Officials
GSK Clinical Trials
Study Director
GlaxoSmithKline
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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