Treatment of Cerebral Toxoplasmosis in HIV/AIDS
Launched by DEPARTMENT OF MEDICAL SERVICES MINISTRY OF PUBLIC HEALTH OF THAILAND · Aug 20, 2006
Trial Information
Current as of June 09, 2025
Completed
Keywords
ClinConnect Summary
Background: Toxoplasmic encephalitis (TE), caused by Toxoplasma gondii, is common in AIDS patients. TE can result in tissue destruction via massive inflammation and brain abscess formation. METHODS: Randomized controlled trials were performed in AIDS patients to assess which drug regimen was optimally effective for the treatment of TE. AIDS patients with TE were randomly divided into 3 groups that received a 6-week course of either pyrimethamine (50 mg/ day or 100 mg/day) plus sulfadiazine (4 g/day) and folinic acid (25 mg/day) or trimethoprim (10 mg/kg/day) plus sulfamethoxazole (50 mg/kg/...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • AIDS
- • Age \> 16 years
- • Clinical Diagnosis of Cerebral toxoplasmosis, Toxoplasmic encephalitis
- • Positive serum titer for Toxoplasma gondii or Positive CSF titer for Toxoplasma gondii after treatment within 2 weeks
- • CT scan suspected toxoplasmosis, ring enhancing lesion
- • CD4\<200
- Exclusion Criteria:
- • Sulfa drugs allergy
- • positive lymphoma cell cytology in CSF
- • no informed consent by patients or first degreee relatives
- • CD4 \>200
About Department Of Medical Services Ministry Of Public Health Of Thailand
The Department of Medical Services, under the Ministry of Public Health of Thailand, is dedicated to advancing healthcare through rigorous clinical research and innovative medical practices. As a key sponsor of clinical trials, the department aims to enhance public health outcomes by evaluating new treatments, improving healthcare delivery, and ensuring the safety and efficacy of medical interventions. With a commitment to ethical standards and scientific integrity, the department collaborates with various stakeholders to address critical health challenges and promote evidence-based practices within the Thai healthcare system.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chiang Mai, , Thailand
Patients applied
Trial Officials
Subsai Kongsaengdao, M.D.
Principal Investigator
Department of Medical Services Ministry of Public Health of Thailand
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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