Estimation of Intrinsic Positive End-Expiratory Pressure (PEEP) in Acute Respiratory Distress Syndrome (ARDS)

Launched by TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER, EL PASO · Mar 12, 2007

Keywords

ClinConnect Summary

Intrinsic PEEP (Positive-End Expiratory Pressure) was measured by end-expiratory occlusion method and estimated using formulas derived from measured expiratory flows and a postulated linear pressure-flow relationship during expiration in passive ARDS patients. Agreement between measured and estimated intrinsic PEEP was analyzed by Bland and Altman's method.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients 18 years of age or older with diagnosis of ARDS, as defined by the American- European Consensus Conference 4
• • Receiving mechanical ventilation.
• • Presence of autoPEEP by inspection of flow-time waveforms displayed by the mechanical ventilator.
• Exclusion Criteria:
• • Known or suspected diagnosis of COPD or airflow limitation.
• • Next of kin not available to consent.
• • Contraindication to receive a muscle relaxant when measurements may be inaccurate without its administration.
• • Pregnancy