Effect of Diet Plus Sibutramine on Hormonal and Metabolic Features in Overweight and Obese Women With PCOS
Launched by HIPPOCRATION GENERAL HOSPITAL · Apr 19, 2007
Trial Information
Current as of May 05, 2025
Completed
Keywords
ClinConnect Summary
The Polycystic Ovary Syndrome (PCOS) is one of the most common hormonal disorders in women of reproductive age. As a syndrome it has multiple components, such as reproductive (chronic anovulation and infertility), metabolic and cardiovascular. Although lean women present PCOS, obesity is one of the main manifestations of the syndrome. Androgen excess and insulin resistance underline much of the clinical and metabolic features of the syndrome.
Recent evidence suggests that PCOS patients have a substantial risk for the development of metabolic and cardiovascular abnormalities similar to thos...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • overweight and obese women with PCOS
- Exclusion Criteria:
- • Nonclassical 21-hydroxylase deficiency, hyperprolactinemia, adrenal or ovarian tumor and Cushing's disease, hypertension, thyroid dysfunction, overt diabetes mellitus and concomitant treatment such as antihypertensive drugs, SSRI or other SNRI drug, oral contraceptive pills or any other antiandrogen treatment (cyproterone acetate, spirolactone, LHRH agonist) and insulin sensitizing agents (metformin, pioglitazone, roziglitazone) that may interact with insulin sensitivity and lipid profile.
About Hippocration General Hospital
Hippocration General Hospital is a renowned healthcare institution dedicated to advancing medical research and improving patient outcomes through innovative clinical trials. With a commitment to high ethical standards and rigorous scientific methodology, the hospital collaborates with leading researchers and healthcare professionals to explore new treatments and therapies across various medical fields. By fostering a patient-centered approach and leveraging state-of-the-art facilities, Hippocration General Hospital aims to contribute significantly to the global body of medical knowledge and enhance the quality of care provided to its community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Thessaloniki, , Greece
Patients applied
Trial Officials
Dimos Florakis, MD
Principal Investigator
Divison of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Greece
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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