Coronary Artery Bypass Surgery (CABG) Off or On Pump Revascularization Study

Launched by POPULATION HEALTH RESEARCH INSTITUTE · Apr 19, 2007

Keywords

ClinConnect Summary

Rationale and purpose of the study:

Coronary artery bypass grafting (CABG) surgery prolongs life-expectancy in patients with severe ischemic heart disease, especially those with left main, triple vessel disease or single/double vessel disease with stenosis of the proximal left anterior descending (LAD) artery. The perioperative mortality is about 2% with an additional 5% to 7% suffering complications such as myocardial infarction, stroke, renal failure, etc. The technique of operating on a beating heart (off-pump) for coronary artery bypass grafting surgery has been recently developed in t...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Patients who have been diagnosed with coronary artery disease (single, double or triple disease) will be eligible if they:
• • 1. require isolated CABG with median sternotomy
• • 2. are able to give their informed written consent
• • 3. are\> 21 years of age and
• 4. have one or more of the following risk factors:
• • ≥ 70 years
• • peripheral vascular disease (previous peripheral bypass or amputation or ABI \<0.80)
• • Cerebrovascular disease (history of stroke, TIA)
• • Renal insufficiency (creatinine above upper limit of normal)
• * \>60 years of age and one of the following:
• • diabetes (oral hypoglycemic agent and/or insulin)
• • urgent revascularization (waiting in hospital)
• • LV ejection fraction \<35%
• • current or recent smoker.
• * 55-59 years of age and two of the following:
• • diabetes (oral hypoglycemic agent and/or insulin)
• • urgent revascularization (waiting in hospital)
• • LV ejection fraction \<35%
• • current or recent smoker.
• Exclusion Criteria:
• Patients will be excluded if they have one of the following:
• • 1. concomitant cardiac procedure associated with CABG,
• • 2. contra-indications to off-pump CABG or on-pump CABG (calcified aorta, intramuscular LAD, calcified coronaries, small target vessels)
• • 3. concomitant life-threatening disease likely to limit life expectancy to less than 2 years,
• • 4. prior enrollment in this trial
• • 5. emergency CABG surgery (immediate revascularization for hemodynamic instability) OR
• • 6. redo CABG.