Early Cardioprotective Effect of Sevoflurane
Launched by UNIVERSITY HOSPITAL DUBRAVA · May 23, 2007
Trial Information
Current as of June 10, 2025
Completed
Keywords
ClinConnect Summary
Studies have been performed on human patients undergoing CABG surgery with cardiopulmonary bypass (CPB). Only a few studies however have evaluated the effects of volatile anesthetics during coronary artery bypass grafting on a beating heart (OPCABG) with conflicting results as far as cardiac biomarker release is concerned.
Because CPB is known to have a profound impact on cardiac function, studies performed on patients scheduled for OPCABG could evaluate more specifically the effects of the anesthetic agents themselves. Patients undergoing OPCABG have a predictable and predefined ischemic ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • the degree I or II of Cardiac Anesthesia Risk Evaluation score
- • angiographically verified coronary artery disease
- • left ventricular ejection fraction higher than 40%
- Exclusion Criteria:
- • atrioventricular conduction disturbances
- • previously ventricular arrhythmias requiring antiarrhythmic treatment
- • atrial fibrillation with rapid ventricular response
- • myocardial infarction or stroke within 6 months
- • diabetes mellitus
- • end-stage of obstructive or restrictive pulmonary disease
About University Hospital Dubrava
University Hospital Dubrava is a leading academic medical center located in Croatia, dedicated to advancing healthcare through innovative research and clinical trials. As a sponsor, the hospital emphasizes a multidisciplinary approach, leveraging its extensive network of healthcare professionals and researchers to conduct high-quality clinical studies. Committed to improving patient outcomes, University Hospital Dubrava focuses on a wide range of therapeutic areas, aiming to translate scientific discoveries into effective treatments while ensuring the highest standards of patient safety and ethical conduct in all research endeavors.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Zagreb, , Croatia
Patients applied
Trial Officials
Ino Husedzinovic, MD PhD Prof
Principal Investigator
Anesthesiology and Intensive Medicine
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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