Loop Diuretics in Chronic Kidney Disease

Launched by UNIVERSITY OF CAMPANIA LUIGI VANVITELLI · May 24, 2007

Keywords

ClinConnect Summary

In CKD, impairment of renal function causes fluid and sodium retention and consequently expansion of extracellular volume, which corresponds to about 5% of body weight in absence of peripheral edema. In particular, sodium retention increases exponentially as glomerular filtration rate declines and is of primary importance in the pathogenesis of hypertension. Therefore, reduction of salt intake in renal patients allows a better blood pressure control. Despite the evidence collected on the beneficial effects of salt restriction in CKD, compliance with dietary prescription is generally poor in...

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Eligibility criteria

• Inclusion Criteria:
• • Chronic renal insufficiency in stage CKD 3 and 4 (GFR 60-15 ml/min/m2) estimated by Cockcroft-Gault formula corrected for body surface
• • Systolic blood pressure \>140 mmHg in treatment with at least 1 class of antihypertensive drugs
• • Patients not in treatment from at least one month with loop diuretics
• Exclusion Criteria:
• • Loop diuretics treatment
• • Variation of serum creatinine \>30% in the last 3 months
• • Steroid therapy and/or cytotoxic agents
• • Edema syndromes (Nephrotic syndrome, cirrhosis, heart failure NYHA class 3 or 4)
• • Neoplasia