Study of Mechanisms of Anovulation in Polycystic Ovary Syndrome

Launched by UNIVERSITY HOSPITAL, LILLE · Jun 26, 2007

Keywords

ClinConnect Summary

Women with PCOS (Rotterdam definition) whom anovulation is resistant to clomiphene citrate will receive recombinant FSH using the low-dose step-up protocol during only one cycle. Serum levels of estradiol, AMH, LH, FSH, inhibin B and ultrasound (U/S) parameters will be assessed twice a week until 3 days after appearance of \> 1 dominant follicle(s).The starting dose of recFSH will be 50 IU/day. In the absence of criteria for dominance (see below) after 14 days at 50 IU/day, recFSH dose will be increased by 25 IU/day every 7 days until dominance is achieved. Dominance will be defined by the ...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • normal sperm analysis in the partners and normal hysterosalpingography in all patients
• • PCOS defined by Rotterdam criteria
• • resistance to clomiphene citrate, i.e. no ovulation at 150 mg/day or no pregnancy after 6 ovulatory cycles
• • informed consent before inclusion
• Exclusion Criteria:
• • on-going pregnancy
• • age\<18 or \>40 yr.
• • unability to understand the treatment protocol
• • other medications
• • any co-existent morbid condition contra-indicating a pregnancy