Use of Formula Fortified With DHA in Infants With Cystic Fibrosis

Launched by UNIVERSITY OF MASSACHUSETTS, WORCESTER · Sep 13, 2007

Keywords

ClinConnect Summary

This study brings together several areas of CF and non-CF research: the finding that CF knock-out mice exhibit an abnormality in AA/DHA ratio in membrane bound fatty acids from tissue which expresses CFTR; the fact that very high doses of DHA fed to CF knock-out mice can correct many of the abnormalities seen in these animals; research on fatty acid content in human breast milk; the effects of breast feeding in CF; and the fact that newborn screening for CF is becoming more widespread and may allow for therapeutic interventions very early in life. This is the first study of which we are awa...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Infant diagnosed with CF and enrolled by 56 days of life
• • Parental consent obtained
• Exclusion Criteria:
• • History of meconium ileus at birth that is resolved without surgical intervention (ie enema)
• • History of bowel resection for any reason
• • Breast feeding
• • Premature birth (\<34 weeks gestation)
• • Severe cholestasis (Direct Bilirubin \> 2x upper limit of normal for age)
• • Severe hypoalbuminemia (Albumin \< 2.5 gm/dl)