Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle

Launched by MEDICAL RESEARCH COUNCIL · Dec 25, 2007

Keywords

ClinConnect Summary

OBJECTIVES:

* To assess whether a reduced computed tomography (CT) schedule or magnetic resonance imaging (MRI) could be used as safe and effective alternatives to standard CT-based surveillance in the management of patients with stage I seminoma of the testis.

OUTLINE: This is a multicenter study. Patients are randomized to 1 of 4 surveillance arms.

* Arm I: Patients undergo computed tomography (CT) scan of the abdomen/retroperitoneum\* at 6, 12, 18, 24, 36, 48, and 60 months in the absence of disease progression.
* Arm II: Patients undergo CT scan of the abdomen/retroperitoneum\* at 6,...

Gender

MALE

Eligibility criteria

• DISEASE CHARACTERISTICS:
• • Histologically confirmed seminoma of the testis
• • Stage I disease, as determined by clinical examination and CT scan of the chest, abdomen, and pelvis
• • No evidence of any non-seminoma germ cell tumor elements
• • Has undergone orchidectomy within the past 8 weeks
• • Normal serum alpha-fetoprotein pre-orchidectomy and at study randomization
• • Normal serum beta human chorionic gonadotrophin at study randomization (may have been elevated pre-orchidectomy)
• • Not planning to undergo adjuvant therapy
• PATIENT CHARACTERISTICS:
• • Able to attend regular surveillance
• • No other malignancy within the past 10 years expect successfully treated nonmelanoma skin cancer
• • No contraindication to MRI (i.e., ferrous metal implants of any type, cardiac pacemaker or defibrillator, or history of injury by metal fragments)
• PRIOR CONCURRENT THERAPY:
• • See Disease Characteristics