Transcranial Magnetic Stimulation to Improve Speech in Aphasia
Launched by BOSTON UNIVERSITY · Jan 24, 2008
Trial Information
Current as of May 23, 2025
Completed
Keywords
ClinConnect Summary
OBJECTIVE: The purpose of this research is to investigate whether repetitive transcranial magnetic stimulation (rTMS) can improve speech in chronic stroke patients with aphasia. TMS allows painless, noninvasive stimulation of brain cortex (1 cm x 1 cm). Slow (1 Hz) rTMS appears to decrease excitability in the targeted cortical region of interest (ROI) leading to measurable behavioral effects. Chronic aphasia patients have been observed in our fMRI work (and others) to have increased activation in right (R) Broca's and other R language homologues during language tasks. It is hypothesized tha...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Right Handed
- • Single, Left Hemisphere Cerebrovascular Stroke
- • Must be at least 6 months poststroke onset
- • Native Speaker of English
- • Clinical Diagnosis of Aphasia
- Exclusion Criteria:
- • Intracranial metallic body from prior neurosurgical procedure
- • Implanted metallic devices: pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit or ventriculoperitoneal shunt
- • Past history of seizure within 1 year
- • Pregnancy
- • History of substance abuse within last 6 months
About Boston University
Boston University, a leading research institution located in Boston, Massachusetts, is dedicated to advancing health sciences through innovative clinical trials and research initiatives. With a strong emphasis on interdisciplinary collaboration, the university leverages its extensive network of experts and state-of-the-art facilities to conduct rigorous clinical studies aimed at improving patient outcomes and addressing pressing health challenges. Boston University is committed to ethical research practices, patient safety, and the dissemination of findings to foster greater understanding and advancements in medical care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Boston, Massachusetts, United States
Philadelphia, Pennsylvania, United States
Patients applied
Trial Officials
Margaret A Naeser, Ph.D.
Study Chair
Department of Neurology, Boston University School of Medicine, Boston, MA
H B Coslett, M.D.
Principal Investigator
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA
Alvaro Pascual-Leone, M.D., Ph.D.
Principal Investigator
Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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