Lopinavir/Ritonavir Monotherapy in Children
Launched by THE HIV NETHERLANDS AUSTRALIA THAILAND RESEARCH COLLABORATION · Feb 28, 2008
Trial Information
Current as of April 27, 2025
Completed
Keywords
ClinConnect Summary
The commonly used antiretroviral (ARV) regimen in the Thai National Access to Antiretroviral Program for People Living with HIV/AIDS is non-nucleoside reverse transcriptase (NNRTI) based HAART. However, one of the most challenging concerns of antiretroviral therapy is the emergence of drug resistance mutants which occurs in 30-40% of treated patients. Children failing nucleoside reverse transcriptase inhibitor (NRTI)/NNRTI regimens have limited options for second line therapy especially in a developing country such as Thailand.
At HIV-NAT, the Thai Red Cross AIDS Research Centre, we had a ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. HIV infected children ages 2 to 18 years
- • 2. Treated with double boosted PIs during the last three months
- • 3. Two consecutive plasma HIV-RNA levels \< 50 copies/ml at least 3 months apart
- • 4. Willing to restart HAART with the same regimen as before enrollment, when indicated
- • 5. Signed written informed consent
- Exclusion Criteria:
- • 1. Active AIDS-defining disease at screening
- • 2. Pregnancy
About The Hiv Netherlands Australia Thailand Research Collaboration
The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT) is a leading international clinical trial sponsor dedicated to advancing research in HIV prevention, treatment, and care. Established through a partnership between renowned institutions in the Netherlands, Australia, and Thailand, HIV-NAT focuses on innovative, evidence-based strategies to improve health outcomes for diverse populations affected by HIV. By fostering collaborative research initiatives, the organization aims to generate impactful data that informs clinical practices and public health policies, ultimately contributing to the global fight against HIV/AIDS.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bangkok, , Thailand
Bangkok, , Thailand
Khon Kaen, , Thailand
Patients applied
Trial Officials
Praphan Phanuphak, MD, PhD
Principal Investigator
HIV-NAT, Thai Red Cross - AIDS Research Centre
Pope Kosalaraksa, MD
Principal Investigator
Department of Pediatrics, Khon Kaen University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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