Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities

Launched by AALBORG UNIVERSITY HOSPITAL · Feb 26, 2008

Keywords

ClinConnect Summary

Deep-venous thrombosis (DVT) remains a common clinical problem (annual incidence 0.10-0.16%) and long-term morbidity as chronic venous insufficience (CVI) in 10-30%.

As to recurrent DVT, initial treatment with Low-Molecular-Weight Heparin ( to-day's terminology Fractionated Heparin (FH)) and Unfractionated Heparin (UFH) has shown equal efficiency, whereas the efficacy concerning long-term morbidity has only more recently been published.

This study was initiated to compare the efficacy of UFH and FH concerning the incidence of CVI after symptomatic DVT at short-term and long-term follow-up.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • First DVT with or without known risk factors except overt cancer
• • Second DVT more than two years after the first if the patient was without clinical signs of CVI.
• Exclusion Criteria:
• • Contraindication to anticoagulation therapy
• • Candidate to thrombectomy with arterious-venous fistula or thrombolytic therapy
• • Known cancer at the time of the DVT diagnosis
• • Patients unable to cooperate for anticoagulation therapy or manage the tests.