Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients
Launched by ASTRAZENECA · Feb 28, 2008
Trial Information
Current as of May 15, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • subjects presenting type IIa or IIb primary hypercholesterolaemia diagnosed for at least 3 months, in a context of primary prevention with at least two associated cardiovascular risk factors and: (i)either "naive" to all lipid-lowering therapy, (ii)or treated with a statin (treatment ongoing or stopped during the previous 8 weeks)
- Exclusion Criteria:
- • homozygous or heterozygous familial hypercholesterolaemia
- • hypertriglyceridaemia (TG ≥ 4 g/l)
- • subjects at high cardiovascular risk according to the AFSSAPS 2005 definition (coronary artery disease or history of documented vascular disease, high cardiovascular risk type 2 diabetes, subject in primary prevention with a 10-year CHD risk \> 20%)
- • history of adverse events or hypersensitivity to an HMG Co-A reductase inhibitor (particularly a history of myopathy)
- • concomitant use of any drugs not authorized during the study
- • active liver disease with elevation of serum transaminases (ASAT, ALAT) more than twice the upper limit of normal
- • CPK more than 3 times the upper limit of normal
- • moderate or severe renal failure (creatinine clearance \< 6 ml/min)
- • poorly controlled hypothyroidism; poorly controlled hypertension (DBP \> 95 mm Hg and/or SBP \> 180 mm Hg)
About Astrazeneca
AstraZeneca is a global biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative medicines across various therapeutic areas, including oncology, cardiovascular, respiratory, and autoimmune diseases. With a strong commitment to scientific research and patient-centric solutions, AstraZeneca leverages cutting-edge technology and a robust pipeline to address unmet medical needs. The company collaborates with healthcare professionals, academic institutions, and other organizations to advance clinical trials and deliver transformative therapies, aiming to improve health outcomes and enhance the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Montpellier, , France
Paris, , France
Lille, , France
Toulouse, , France
Strasbourg, , France
Blois, , France
Bordeaux, , France
Caen, , France
Dijon, , France
Marseille, , France
Perigueux, , France
Toulon, , France
Amiens, , France
Annecy, , France
Saint Etienne, , France
Angers, , France
Cannes La Bocca, , France
Roubaix, , France
Ivry Sur Seine, , France
Metz, , France
Montigny Les Metz, , France
Yerres, , France
Evreux, , France
Tarare, , France
Belfort, , France
Epernay, , France
Laval, , France
Beziers, , France
Roquevaire, , France
Arles, , France
Aubagne, , France
Biarritz, , France
Epinal, , France
Marcq En Baroeul, , France
Aix En Provence, , France
Bondy, , France
Pau, , France
Nancy, , France
Colomiers, , France
Le Bouscat, , France
Montbeliard, , France
St Etienne, , France
St Girons, , France
Allaire, , France
Ancerville, , France
Anzin, , France
Arthez De Bearn, , France
Aspach Le Bas, , France
Auchel, , France
Bailleul, , France
Balma, , France
Beaucaire, , France
Bersee, , France
Bezenet, , France
Boersch, , France
Bondues, , France
Brignoud, , France
Bruay La Buissiere, , France
Bruges, , France
Cabanac Et Villagrains, , France
Cadaujac, , France
Carnon, , France
Caylus, , France
Cernay, , France
Cestas, , France
Champcueil, , France
Chanceaux Sur Choisille, , France
Chilly Mazarin, , France
Clary, , France
Collioure, , France
Colombier Fontaine, , France
Coulonieix Chamiers, , France
Crecy La Chapelle, , France
Crotenay, , France
Cuise La Motte, , France
Derval, , France
Eckbolsheim, , France
Eckwersheim, , France
Etang Sur Arroux, , France
Fargues St Hilaire, , France
Folembray, , France
Fos Sur Mer, , France
Franconville La Garenne, , France
Gamarde Les Bains, , France
Gambsheim, , France
Gradignan, , France
Grand Couronne, , France
Grendelbruch, , France
Guise, , France
Harnes, , France
Horbourg Wihr, , France
Is Sur Tille, , France
Jarville La Malgrange, , France
Jeumont, , France
La Ciotat, , France
La Courneuve, , France
La Creche, , France
La Francheville, , France
Lacrouzette, , France
Lamagistere, , France
Le Cannet, , France
Le Passage, , France
Leognan, , France
Les Issambres, , France
Lucheux, , France
Maslacq, , France
Mauguio, , France
Meaux Beauval, , France
Mennecy, , France
Mensignac, , France
Merlimont, , France
Miramont De Guyenne, , France
Mittersheim, , France
Monfort En Chalosse, , France
Monguilhem, , France
Mont De Marsan, , France
Montauroux, , France
Monteux, , France
Montfrin, , France
Moreuil, , France
Muespach, , France
Nogent Sur Marne, , France
Noyon, , France
Oberhausbergen, , France
Orchamps, , France
Palau Del Vidre, , France
Pauillac, , France
Pfulgriesheim, , France
Phalempin, , France
Pont A Mousson, , France
Pouilly En Auxois, , France
Poussan, , France
Pradines, , France
Puteaux, , France
Quimperle, , France
Rognac, , France
Rohrwiller, , France
Roncq, , France
Saint Martin D'oney, , France
Saint Medard En Jalles, , France
Saint Remy, , France
Salles, , France
Sarlat La Caneda, , France
Semur En Auxois, , France
Serres Castet, , France
Soissons, , France
Sorcy Saint Martin, , France
St Etienne De Montluc, , France
St Jean De Braye, , France
St Leu La Foret, , France
St Morillon, , France
St Remy De Provence, , France
St. Emilion, , France
Targon, , France
Tartas, , France
Tassin La Demi Lune, , France
Thones, , France
Thun St Amand, , France
Trie Sur Baise, , France
Varces Allieres Et Risset, , France
Vatan, , France
Velizy Villacoublay, , France
Vence, , France
Vieux Boucau, , France
Villard Bonnot, , France
Villette D'anthon, , France
Viry Chatillon, , France
Wasselonne, , France
Wattignies, , France
Wattrelos, , France
Yffiniac, , France
Patients applied
Trial Officials
Michel Farnier, MD
Principal Investigator
Le Point Medical - Rond Point du Jour
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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