Determining the Extent of Diffusion Tensor Abnormalities in Focal Cortical Dysplasia

Launched by THE HOSPITAL FOR SICK CHILDREN · May 26, 2008

Keywords

ClinConnect Summary

Focal cortical dysplasia (FCD) is a highly epileptogenic form of malformation of cortical development that may require surgical resection for epilepsy control. With abnormal development and organization of neurons within the cortex, the white matter projecting from the abnormal cortex is likely to be abnormal as well. The abnormality in the white matter involves not only the subcortical white matter, but also the long tracts in the deep white matter associated with the dysplastic cortex. Histologically, the subcortical white matter adjacent to the dysplastic cortex has been found to be abno...

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Eligibility criteria

• Inclusion Criteria:
• • Children with intractable epilepsy with suspected FCD for MRI \& MEG
• Exclusion Criteria:
• • Children with contraindications to MRI such as those with pacemaker