Citrate- Versus Acetate-Based Dialysate in Bicarbonate Haemodialysis: Consequences on Haemodynamics, Coagulation, Acid-Base Status and Electrolytes
Launched by OSPEDALE REGIONALE DI LOCARNO · Jul 17, 2008
Trial Information
Current as of June 23, 2025
Completed
Keywords
ClinConnect Summary
Introduction:
A concentrate for bicarbonate haemodialysis acidified with citric instead of the less physiologic acetic acid has been successfully implemented in the United States in the past 7 years \[1-3\]. Contrarily to traditional regional citrate anticoagulation, the small amount of citrate used in the acid concentrate (0.8 mmol/L only; about one-fifth of the concentration necessary to achieve anticoagulation \[1,4,5\]) affects the calcium concentration and the locally enhanced coagulation activation in a limited way, resulting in approximately 10% reduction in post-dialysis ionized ca...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • chronic haemodialysis patients
- • dialysed 3 to 4 hours three times a week, who were
- • clinically stable and without intercurrent illnesses
- Exclusion Criteria:
- • intercurrent illnesses
About Ospedale Regionale Di Locarno
Ospedale Regionale di Locarno is a leading healthcare institution in Switzerland, dedicated to advancing medical research and improving patient outcomes through innovative clinical trials. With a commitment to excellence in patient care and a focus on multidisciplinary collaboration, the hospital leverages its state-of-the-art facilities and a team of experienced professionals to conduct a wide range of clinical studies. Ospedale Regionale di Locarno actively engages in research initiatives that address critical health challenges, ensuring adherence to the highest ethical standards and regulatory compliance, thereby contributing to the global advancement of medical knowledge and therapies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Locarno, Ticino, Switzerland
Patients applied
Trial Officials
Luca Gabutti, MD
Principal Investigator
Ospedale Regionale di Locarno
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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