Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases.

Launched by HOSPITAL ARNAU DE VILANOVA · Aug 13, 2008

Keywords

ClinConnect Summary

We will perform non-invasive techniques (carotid Intima-Media Thickness, CAC score and ankle-brachial index) to individuals at intermediate cardiovascular risk.With these results, we will classify participants in: no atherosclerosis, mild, moderate and severe atherosclerosis, and therapeutic targets will be set according to pre-defined algorithms. The end-point will be the course of atherosclerosis measured by cIMT/CAC score (2 years) and the incidence of CVD at 5 years of follow-up.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• One or more of the following:
• • Familiar History of early-onset cardiovascular disease (male \< 55 or female \< 65).
• • Type 2 Diabetes mellitus or type 1 with microalbuminuria.
• • Essential High Blood Pressure.
• • Chronic Kidney Disease.
• • Primary hyperlipidemia.
• The presence of two or more of the following:
• • Current smoker.
• • Physical inactivity.
• • High blood pressure (recently diagnosed).
• • Abdominal perimeter: \> 102 cm. males; \> 88 cm. females.
• • Total cholesterol \> 240 mg/dL.
• • HDL cholesterol ≤ 40 mg/dL males, ≤ 50 mg/dL females.
• Exclusion Criteria:
• • Age \< 40 or \> 74 years old.
• • Previous Cardiovascular Event.