Preoperative Radiotherapy and Local Excision in Rectal Cancer

Launched by POLISH COLORECTAL CANCER STUDY GROUP · Aug 19, 2008

Keywords

ClinConnect Summary

Local excision must involve all tissue invaded on pretreatment examination. For this reason, 4-5 tatoos of mucosa at the tumour border should be performed before the onset of treatment. Next, the long-course radiochemotherapy or short-course radiotherapy is randomly allocated. After 6 weeks interval, the full thickness local excision should be carried out with 1 cm margin. Patients with good pathological response (complete response or downstaging to ypT1 disease)are followed up. Conversion to open surgery is offered to patients with poor pathological response (ypT2-3 or positive margin). Cl...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Biopsy proven good or moderately differentiated adenocarcinoma of rectum
• • Extraperitoneal tumour (\< 3-4 cm; unfavourable cT1 or cT2-3; N0)
• • No evidence of distant metastases on chest X-ray and abdominal CT or sonography
• • Signed by patient written informed consent
• Exclusion Criteria:
• • Poorly differentiated pathology (G3)
• • Patients unfit for chemotherapy
• • No agreement for randomisation