The Efficacy and Safety of Curcuma Domestica Extracts and Ibuprofen in Knee Osteoarthritis

Launched by MAHIDOL UNIVERSITY · Nov 16, 2008

Keywords

ClinConnect Summary

Curcumin was demonstrated to be safe and had anti-inflammatory activity in six studies in humans. It may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation.

Our experience in a study of 100 subjects revealed a trend towards a greater effect in OA patients receiving Curcuma domestica extracts. However, studies with adequate sample and dosage of Ibuprofen are recommended to demonstrate the efficacy of C.domestica extracts in alleviating knee pain and improving knee functions.

The objective of the study was to determine the ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Primary osteoarthritis
• • Knee pain score more than or equal to 5 point (NRS 0-10)
• • Age \>= 50 years, not \> 75 years
• • Knee crepitus
• • Knee stiffness less than 30 minutes
• • Urine pregnancy test negative in case of not being menopausal period
• Exclusion Criteria:
• • History of GI ulcer or melena
• • Having hepatic or bile duct diseases(SGOT ≥ 37 u/L, SGPT ≥ 40 u/L)
• • Having renal disease or abnormal renal functions (serum creatinine ≥ 1.5 mg/dl)
• • Asthma or gout
• • Allergy to ibuprofen or curcumin
• • History of intraarticular knee injection within 6 months
• • Post knee arthroplasty
• • History of intermittent claudication
• • Unable to walk, for example hemiplegia, severe lung/heart diseases
• • Knee x-ray found chondrocalcinosis
• • On anticoagulant

Trial Officials