Effects of Using Betahistine to Treat Adults With Attention Deficit Hyperactivity Disorder

Launched by P2D, INC. · Jan 26, 2009

Keywords

ClinConnect Summary

Attention deficit hyperactivity disorder (ADHD) is a disorder in which problems with paying attention and focusing disrupt people's lives. Betahistine is a drug that activates histamine, a compound found in the human body that regulates immune response and acts as a neurotransmitter. Increased availability of histamine in the brain is known to enhance attention and cognition. In previous studies, betahistine increased vigilance in healthy participants. Presently, betahistine is used outside the United States to treat vertigo, but at doses that are too low to have an effect on attention and ...

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Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of attention deficit hyperactivity disorder (ADHD), combined subtype, using DSM-IV criteria
• • Otherwise healthy, as determined by medical history, physical examination, and clinical laboratory tests
• • Symptomatic impairment with ADHD, as evidenced by a symptom severity score of 20 or greater on the 18-item ADHD total symptom score of the Conners Adult ADHD Rating Scales (CAARS)
• • Body mass index (BMI) less than or equal to 32.4 kg/m2, with a waist circumference less than or equal to 40 inches for males
• Exclusion Criteria:
• • Known allergies to betahistine
• • Participation in a study involving administration of an investigational compound within the past month
• • Pregnant
• • Positive for HIV, hepatitis B antigen, or hepatitis C antibody
• • Use of illicit drugs (excluding psychostimulants for ADHD) or alcohol
• • History of drug addiction or alcohol abuse requiring treatment within the past 12 months
• • History of asthma, peptic ulcer disease, or pheochromocytoma
• • History of any other illness or condition that, in the opinion of the principal investigator, might interfere with study participation, confound the results of the study, or pose additional risk to the subject