Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome

Launched by MARK PIMENTEL, MD · Jul 23, 2009

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Rome III positive IBS subjects (18-75 years of age)
• • Meet criteria for constipation predominant IBS symptoms including ≤ 3 complete spontaneous bowel movements per week with hard or lumpy stools.
• • Presence of detectable methane on single breath sample (≥ 3ppm).
• • If subjects are ≥ 50 years old, a colonoscopy had to have been completed within the past 5 years.
• Exclusion Criteria:
• • Subjects with history of intestinal surgery (except appendectomy or cholecystectomy)
• • Recent antibiotic use (within the last 30 days)
• • Subjects with known pelvic floor dysfunction
• • Pregnancy
• • Creatinine level \> 1.4
• • Poorly controlled/uncontrolled significant medical condition that would interfere with study procedures
• • Subjects with hearing loss and/or tinnitus
• • History of bowel obstruction
• • History of celiac disease
• • History of inflammatory bowel disease
• • Cirrhosis
• • Diabetes