The Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes
Launched by BAYLOR COLLEGE OF MEDICINE · Jul 31, 2009
Trial Information
Current as of May 17, 2025
Completed
Keywords
ClinConnect Summary
A large study in people with type 2 diabetes (T2DM) showed that lowering blood sugars stopped or delayed the occurrence of health problems. As a result of the study, treatment should try to control blood sugars as near to normal as safely possible.
In people without diabetes, the "after meal" blood sugar level is very carefully controlled by several hormones. Insulin (the hormone that lowers blood sugar) and glucagon (hormone that raises blood sugar) play a key role in keeping this careful balance. Also, we now know of 2 new substances made by the body called amylin and GLP-1 that also hel...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Children with Type 2 Diabetes,
- • Between the ages of 12-21 years,
- • Tanner stage 4-5 for pubertal development,
- • Menstruating females must have a negative urine pregnancy test for inclusion,
- • Must have T2DM for at least 6 months,
- • History of negative anti-glutamic acid decarboxylase (GAD) -65 and anti-islet cell antibodies,
- • HbA1c \< 8.5% and on a stable dose of an oral hypoglycemic agent (with or without insulin) over the last 2 months, or well controlled on diet.
- Exclusion Criteria:
- • A history of a chronic disease other than diabetes (leukemia, asthma, inflammatory bowel disease, cystic fibrosis, juvenile rheumatoid arthritis, dyslipidemia, cholelithiasis etc),
- • BMI\> 40 kg/m2,
- • Weight of \< 60 kg,
- • Female with menstrual irregularities,
- • Allergy to local anesthetics (ELAMAX Cream, Ethyl Chloride),
- • Evidence or history of chemical abuse,
- • Anemia (age specific normal range for hemoglobin will be used),
- • Elevated liver enzymes (defined as more than 3 times the upper limit of the normal range for age),
- • Elevated BUN or creatinine (defined as more than 3 times the upper limit of the normal range for age),
- • Use of medications that may increase the blood sugars and admission to the hospital for diabetes related problems over the last 6 months.
About Baylor College Of Medicine
Baylor College of Medicine is a leading academic institution dedicated to advancing health through innovative research, education, and clinical care. Located in Houston, Texas, it is renowned for its commitment to excellence in medical education and translational research, fostering collaborations that bridge laboratory discoveries with clinical application. As a clinical trial sponsor, Baylor College of Medicine leverages its robust infrastructure, interdisciplinary expertise, and access to diverse patient populations to conduct cutting-edge clinical studies aimed at improving patient outcomes and enhancing therapeutic approaches across a wide range of medical conditions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Houston, Texas, United States
Patients applied
Trial Officials
LUISA M RODRIGUEZ, MD
Principal Investigator
Baylor College of Medicine
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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