The Effect of Grape Seed Extract on Blood Pressure in People With Pre-Hypertension

Launched by CLINICAL NUTRITION RESEARCH CENTER, ILLINOIS INSTITUTE OF TECHNOLOGY · Sep 17, 2009

Keywords

ClinConnect Summary

Elevated blood pressure, or hypertension, is a major risk factor for heart disease and stroke. Systolic and diastolic blood pressures meeting criteria for "pre-hypertension" double the absolute risk of stroke and ischemic heart disease over an extended age range from the 4th to the 8th decade of life. Lifestyle, particularly the diet, is critical in the prevention and management of hypertension. Polyphenolic compounds from various plant foods can promote blood pressure regulation and vascular health through protection of the endothelium from oxidant and or inflammatory stress and or stimula...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • male and female
• • pre-hypertensive
• • systolic blood pressure (mmHg) 120 - 139 or
• • diastolic blood pressure (mmHg) 80 -89
• • no clinical evidence of cardiovascular, respiratory, renal, gastrointestinal or hepatic disease
• Exclusion Criteria:
• • pregnant and or lactating
• • taking over the counter antioxidant supplements
• • taking prescription medications that may interfere with study procedures or endpoints
• • unusual dietary habits
• • actively trying to lose or gain weight
• • addicted to drugs and/or alcohol
• • medically documented psychiatric or neurological disturbances
• • smoker (past smoker may be allowed if cessation is \> 2 years)