Following Lipectomy to Understand Adipose Tissue Re-accumulation

Launched by UNIVERSITY OF COLORADO, DENVER · Oct 13, 2009

Keywords

ClinConnect Summary

Lipectomy is the most frequently performed aesthetic surgery in the U.S. today and is considered permanent, by The American Society for Aesthetic Plastic Surgery, but no long term follow-up studies have been done to verify this assertion. Indeed, animal studies suggest rapid adipose tissue (AT) re-accumulation after lipectomy is common and may even be accompanied by unfavorable changes in disease risk. Recent studies in humans have focused on abdominal lipectomy as a means of reducing metabolic disease risk in obese premenopausal women. However, none of these studies evaluated AT re-accumul...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • post-menopausal (no menses for 12mo or oophorectomy w/ follicle-stimulating hormone (FSH)\>30 IU/L) OR- pre-menopausal (regular menses 28+/-3d)
• • BMI \>20 and \<30 kg/m2)
• • weight stable (+/- 2kg in past 2mo)
• • non-smoking
• • no use of hormone therapies or oral contraceptives
• • actively seeking liposuction of the hips and thighs
• • good femoral lipectomy candidates as determined by cosmetic surgeon
• Exclusion Criteria:
• • severe hypertriglyceridemia (\>400 mg/dL)
• • medications known to affect lipid metabolism
• • elevated resting blood pressure (Systolic \>140 mm Hg,Diastolic \>90 mm Hg)
• • history of lipectomy or gastric bypass surgery
• • body dysmorphic disorder
• • pregnant, lactating or intention of becoming pregnant
• • indication of high surgical risk (e.g., abnormal resting ECG, history of thromboembolism, valvular heart disease)