The Effect of Remote Ischemic Preconditioning in the Cardiac Surgery
Launched by SEOUL NATIONAL UNIVERSITY HOSPITAL · Oct 16, 2009
Trial Information
Current as of June 04, 2025
Completed
Keywords
ClinConnect Summary
Perioperative myocardial injury is a serious complication of cardiac surgery. This complication increases both mortality and morbidity of cardiac surgery. Remote ischemic preconditioning (RIPC) is the concept that brief ischemia followed by reperfusion in an organ can reduce subsequent ischemia-reperfusion injury in distant organs. Recent several clinical trials showed powerful myocardial protective effect of remote ischemic preconditioning by reducing postoperative cardiac enzymes. However, the evidence that remote ischemic preconditioning can improve the clinical outcomes such as mortalit...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • adult patients undergoing cardiac surgery
- Exclusion Criteria:
- • emergent operation
- • preoperative use of inotropics or mechanical assist device,
- • left ventricular ejection fraction less than 30%,
- • severe liver, renal and pulmonary disease,
- • recent myocardial infarction (within 7 days),
- • recent systemic infection or sepsis (within 7 days)
- • peripheral vascular disease affecting upper limbs
- • amputation of the upper limbs
- • major combined operation such as aortic surgery or carotid endarterectomy
- • descending thoracic aortic surgery
- • rare surgeries; cardiac transplantation, correction of complicated congenital anomalies, pulmonary thromboembolectomy, etc
About Seoul National University Hospital
Seoul National University Hospital (SNUH) is a leading medical institution in South Korea, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent clinical trial sponsor, SNUH integrates cutting-edge scientific inquiry with patient-centered care, facilitating the development of novel therapies and treatment protocols. The hospital boasts a diverse range of specialized departments and a robust infrastructure for conducting clinical studies, ensuring rigorous adherence to ethical standards and regulatory compliance. By fostering collaboration among multidisciplinary teams, SNUH aims to contribute significantly to global medical advancements and improve patient outcomes.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Seoul, , Korea, Republic Of
Patients applied
Trial Officials
YunSeok Jeon, professor
Study Director
Department of Anesthesiology and Pain Medicine, SNUH
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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