N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder (OCD)

Launched by CHINA MEDICAL UNIVERSITY HOSPITAL · Dec 14, 2009

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Eligibility criteria

• Inclusion Criteria:
• • a primary OCD according to DSM-IV
• • at least 1 year's duration of OC symptoms and a minimum severity score of ≥16 on Yale-Brown Obsessive Compulsive Scale
• • drug naïve at study entry or
• • being free from psychotropic medication for at least 8 weeks at study entry,or
• • inadequately responded to ongoing psychotropic medications at study entry (defined by a Y-BOCS score of ≧16 despite treatment with maximum tolerated dose of a SRI medication for at least 8 weeks)
• Exclusion Criteria:
• • patients with moderate to severe depression defined by a 21-item Hamilton Depression Rating Scale score of \>17,
• • a history of bipolar disorder, schizophrenia, schizoaffective disorder, or other psychosis as defined by DSM-IV, or if they were at significant risk of suicide, and
• • with clinically significant organic disease including cardiovascular, hepatic, pulmonary, neurologic, metabolic, or renal disease