AIDA 2000 Guidelines

Launched by GRUPPO ITALIANO MALATTIE EMATOLOGICHE DELL'ADULTO · Feb 5, 2010

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ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>= 1 years and \< 61 years
• • Morphologic diagnosis of APL
• • PS \<= 3
• • Presence in leukemic cells at diagnosis of t(15;17), and/or PML/RARa rearrangement by RT-PCR. T
• • The presence of additional cytogenetic lesions is not considered an exclusion criterion
• • Serum creatinine \<=2.5 mg/dL
• • Serum bilirubin, alkaline phosphatase, or GOT/ASAT \<= 3 times the upper normal limit
• • Negative pregnancy test
• • Written informed consent
• Exclusion Criteria:
• • Age \>= 61 years
• • Prior antileukemic chemotherapy for APL
• • Absence of PML-RARa rearrangement after successful RNA extraction and amplification of control gene
• • Prior antileikemic chemotherapy for APL
• • Presence of a concomitant malignant neoplasm, except basal cell carcinoma Concurrent treatment with cytotoxic chemotherapy or radiotherapy
• • Oteher progressive malignant disease. However, secondary acute promyelocytic leukemia following "cured" Hodgkin's disease or otehr cured malignancies may be included, as well as secondary leukemias following other exposure to alkylating agents or radiation for other reasons