Metabolic Effects of Birth Weight on Overweight and Obese Chinese Adults and Their Responses to Weight Loss

Launched by NATIONAL UNIVERSITY HOSPITAL, SINGAPORE · Mar 3, 2010

Keywords

ClinConnect Summary

There is an exponential rise in the prevalence of type 2 diabetes and obesity in Singapore coincident with rapid nutritional and socioeconomic transition. Differing birth weights, even in the normal ranges, predisposes individuals to the risk of type 2 diabetes and obesity. We aim to examine the causal pathways, developmental contribution and effects of a weight loss intervention to this differential by evaluating the hypothesis that genomic, birth weight, developmental, lifestyle and environmental factors contribute to the variation in phenotype observed in adults with obesity and metaboli...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Ability to give informed consent
• • 2. Chinese males (aged 21-40)
• • 3. Body mass index between 23-30 kg/m2
• • 4. Total body fat content \>24%
• • 5. Sedentary adults \< 1 episode of exercise \> =30 min/week
• • 6. Birth weight between 5-95% percentiles
• • 7. Fasting glucose \< 7 mmol/L
• • 8. Normotensive, defined as BP \< 140/90 mmHg and not on any antihypertensive agents
• Exclusion Criteria:
• • 1. Recent changes in weight of \>5% over the past 6 months
• • 2. Attempts to lose weight (weight not stable, exercises still changing and not in maintenance phase) over the past 6 months
• • 3. Significant changes in diet over the past 6 months
• • 4. Any use of weight reducing drugs in the past 6 months
• • 5. Previous abdominal surgery (and bariatric surgery)
• • 6. Any bleeding disorders which would preclude biopsies
• • 7. Any use of investigational drugs in the past 6 months
• • 8. Known allergy to insulin or local anaesthetics
• • 9. Known allergy to milk or milk products (eg. Ensure, liquid meal)
• • 10. Any serious illness requiring hospitalization or surgery in the past 6 months
• • 11. Treatment with medications for hypertension, diabetes mellitus or dyslipidemia, epilepsy, ischemic heart disease
• • 12. On anti-platelet agents, non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulants
• • 13. Use of any prescription medication that cannot be safely discontinued within 14 days prior to study entry
• • 14. Any use of corticosteroids in the past 6 months
• • 15. Any other medications that could alter insulin resistance
• • 16. History of surgery with metallic clips, staples or stents
• • 17. Presence of cardiac pacemaker or other foreign body in any part of the body including tattoos
• • 18. Mother no longer alive or unable to provide information on birth weight
• • 19. Born premature (ie. not full term baby \< 37 weeks of gestation age)