Dextromethorphan and Silymarin in Chronic Kidney Disease (CKD) Patients

Launched by NATIONAL CHENG-KUNG UNIVERSITY HOSPITAL · Mar 22, 2010

Keywords

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with Stage 3 or 4 chronic kidney disease as measured by a Modification in Diet in Renal Disease Study (MDRD) estimate of between 15 ml/min and 59 ml/min and and 0.5 g/day\<proteinuria\<3g/day.
• • 2. Age between 18 and 75 years old.
• • 3. Patients without hospitalization for cardiac or infection related morbidity over the previous 2 months(due to the potential confounding effects on baseline study variables).
• • 4. Patients who are able to provide consent to participate in the study.-
• Exclusion Criteria:
• • 1. patients will significant mental illness, pregnant women, and other vulnerable populations.
• • 2. Patients with active hepatic disease and/or ALT \> 2.5 times upper limit of normal.
• • 3. Patients with history of congestive heart failure and NYHA Class III-IV symptoms at any time.
• • 4. Patients for whom living donor renal transplantation is already scheduled or in the process of being evaluated, as these patients will be unlikely to complete study protocols before transplantation.
• • 5. Patients with severe co-morbid conditions (eg, symptomatic hepatic cirrhosis, metastatic cancer, HIV infection with AIDS).
• • 6. Patient with active inflammatory process (eg., SLE, rheumatoid arthritis, gout) for which they are currently receiving immune modulating medications.
• • 7. Patients who are on corticosteroid therapy.
• • 8. Patients who do not consent to participate in the study.