Gonadotropin-releasing Hormone (GnRH) Antagonist During 3 Days

Launched by UNIVERSITAIR ZIEKENHUIS BRUSSEL · Mar 24, 2010

Keywords

ClinConnect Summary

A recently accepted study demonstrated that raised progesterone levels can be normalized through administration of a GnRH antagonist during three subsequent days prior to the start of gonadotropin stimulation in a GnRH antagonist protocol. This regimen, after normalisation of the progesterone value, allows controlled ovarian hyperstimulation (COH). Since this regimen is valid in case of elevated progesterone, GnRH antagonists pretreatment may prove to be a valid tool for scheduling IVF treatment in patients with normal progesterone values on day 2 of the cycle. In this prospective randomise...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • \< 39 years old on day of randomisation
• • FSH \< 12 (in the early follicular phase)
• • Normal ultrasound scan, i.e. presence of both ovaries, without evidence of abnormality within 6 months prior to randomisation.
• • Regular menstrual cycles of 21-35 days, presumed to be ovulatory.
• • BMI between 18 and 29 (both inclusive)
• • 1st or 2nd trial
• • IVF or ICSI
• • Randomisation at out-patient clinic
• Exclusion Criteria:
• • ≥ 39 years old on day of randomisation
• • Endometriosis ≥ grade 3
• • PCOS