LV Diastolic Dysfunction Among the Patients With Systolic Heart Failure-clinical Significance and Prognostic Importance.

Launched by MEIR MEDICAL CENTER · May 2, 2010

Keywords

ClinConnect Summary

Recent studies have explored the prognostic role of TDI-derived parameters in major cardiac diseases, such as heart failure, acute myocardial infarction, and hypertension.(1-3). In these conditions, myocardial mitral annular or basal segmental (Sm) systolic and early diastolic (Ea or Em) velocities have been shown to predict mortality or cardiovascular events. In particular, those with reduced Sm or Em values of \<3 cm/s have a very poor prognosis. In heart failure and after myocardial infarction, noninvasive assessment of LV diastolic pressure by transmitral to mitral annular early diastol...

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Eligibility criteria

• Summary of Subject Eligibility criteria:
• • Men and women \>18 years of age.
• • HF of\> 3 mo duration and NYHA class II, III, or IV at time of randomization.
• • LVEF \<45%
• • Blood pressure \<160/100
• • No HF primarily due to valvular heart disease and no clinically significant valvular heart disease that might lead to surgical correction within 12 months of randomization.
• • No implantable ICD or CRT within 30 days prior to randomization.
• • No chemo- or radio-therapy for treatment of a malignancy within 6 months prior to randomization or clinical evidence of current malignancy with the following exception: local BCC of the skin or cervical intraepithelial neoplasia.
• • Serum creatinine\<2.5 mg/dl